Actively Recruiting
Determination of ED50 and ED95 With Clinical Efficacy of Intranasal Dexmedetomidine Combined With Esketamine for Preoperative Sedation in Pediatric General Anesthesia
Led by Second Affiliated Hospital of Wenzhou Medical University · Updated on 2025-12-02
80
Participants Needed
2
Research Sites
39 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
For pediatric patients undergoing general anesthesia, poor anesthesia induction compliance often has adverse effects on individual behavior in the early postoperative period. Dexmedetomidine can reduce the cardiovascular responses and postoperative mental adverse reactions caused by esketamine anesthesia induction \[6\]. This study aims to explore the ED50 and ED95 and clinical effects of the combination of dexmedetomidine and esketamine nasal drops for preoperative sedation in children of different ages undergoing general anesthesia, providing a theoretical basis for the combined use of dexmedetomidine and esketamine for preoperative sedation in children undergoing general anesthesia.
CONDITIONS
Official Title
Determination of ED50 and ED95 With Clinical Efficacy of Intranasal Dexmedetomidine Combined With Esketamine for Preoperative Sedation in Pediatric General Anesthesia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- ASA physical status classification Grade I or II
- Age 1 to 6 years old
- Children scheduled for elective surgery requiring general anesthesia
- Weight within the normal range
- Signed informed consent form
You will not qualify if you...
- Child or guardian refuses to participate
- Contraindications to sedation or anesthesia or history of abnormal recovery
- Known allergy to study drugs, opioid drugs, or rescue medications
- History of heart, brain, liver, kidney, or metabolic diseases
- Upper respiratory tract infection within the past two weeks
- Other diseases that may harm the participant
AI-Screening
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Trial Site Locations
Total: 2 locations
1
The second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University
Wenzhou, Zhejiang, China, 325000
Not Yet Recruiting
2
The second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University
Wenzhou, Zhejiang, China, 325000
Actively Recruiting
Research Team
H
Huacheng Liu
CONTACT
C
Chenrui Zhou
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
TREATMENT
Number of Arms
2
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