Factors Affecting Immune Response After Allogeneic Hematopoietic Stem Cell Transplantation

What this Trial Is About

Researchers are studying donors and patients undergoing allogeneic hematopoietic stem cell transplantation to understand how different immune cell types in the graft affect immune recovery after transplant. The study aims to analyze various immune effector T cells and immunoregulatory cell subtypes, and see how these relate to important clinical outcomes like graft-versus-host disease, relapse, and infections. A related part of the research will also examine how changes in the gut microbiota affect immune responses and regulatory cells after transplant. Participants include both stem cell donors and patients receiving the transplant. The study involves collecting additional blood samples and bone marrow aspirations at multiple time points before the graft, and then at days 0, 7, 15, 21, 30, 60, 90, 180, 1 year, and 2 years after transplant. These samples help assess the immune cell populations and stem cell graft content over time. Throughout the study, researchers will monitor the proportions of regulatory immune cells in the blood, as well as track clinical events such as graft-versus-host disease, relapse, infections, progression-free survival, and overall survival at the same time points. The study participation may last up to two years, with regular evaluations and sample collections to understand the immune recovery and clinical outcomes following transplantation.

Determination of Factors Involved in the Regulation of Immune Responses After Allogeneic Hematopoietic Stem Cell Transplantation