Actively Recruiting
Determination of Microbiological Factors Associated With Poor Response to Neoadjuvant Treatment in Rectal Cancers
Led by Institut du Cancer de Montpellier - Val d'Aurelle · Updated on 2025-02-12
220
Participants Needed
2
Research Sites
524 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The objective of this project is to determine in a non-invasive manner (fecal samples) the predictive value of the intestinal microbiota and the presence of genotoxin-producing bacteria on the response to neoadjuvant treatment in rectal cancer. This could lead to a better understanding and selection of patients for personalized treatment in rectal cancer.
CONDITIONS
Official Title
Determination of Microbiological Factors Associated With Poor Response to Neoadjuvant Treatment in Rectal Cancers
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Histologically proven lower and mid-rectal adenocarcinoma at clinical stage II and III
- Planned neoadjuvant treatment including radiochemotherapy, chemotherapy, or radiotherapy; induction chemotherapy such as folfox or folfirinox allowed
- Signed informed consent for the study
- Male or female aged 18 years or older
- Use of appropriate contraceptive measures by men and non-menopausal women before and at least 8 weeks after last radiochemotherapy course
You will not qualify if you...
- Antibiotic treatment at the time of or within one month before stool sampling
- Presence of an ostomy
- Previous treatment for rectal cancer
- Not affiliated with a French social protection system
- Poor treatment compliance due to psychological, family, social, or geographical reasons
- Legal incapacity such as under curatorship or guardianship
- Prior radiation therapy or pelvic curia within one year before inclusion
- History of other cancers in the last 5 years except treated in-situ cervical carcinomas or non-melanoma skin carcinomas
- Pregnant or breastfeeding women
AI-Screening
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Trial Site Locations
Total: 2 locations
1
Institut régional du Cancer de Montpellier
Montpellier, Hérault, France, 34298
Actively Recruiting
2
CHU Clermont-Ferrand
Clermont-Ferrand, Puy De Dôme, France, 63000
Not Yet Recruiting
Research Team
A
Aurore MOUSSION, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
OTHER
Number of Arms
1
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