Actively Recruiting
Determination of the Optimal Volume of Liposomal Bupivacaine in Adductor Canal Block for Knee Joint Surgery
Led by Nanjing First Hospital, Nanjing Medical University · Updated on 2025-09-08
63
Participants Needed
1
Research Sites
134 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Building on Bayesian design methodologies from volume optimization studies of ropivacaine in shoulder surgery, this study pioneers the application of a seamless dose-finding strategy in knee ACB. Utilizing advanced statistical models (BOIN/BOP2 design), we aim to systematically evaluate the volume-effect relationship of liposomal bupivacaine, providing precise dosing recommendations to advance personalized and optimized analgesic protocols for knee surgery.
CONDITIONS
Official Title
Determination of the Optimal Volume of Liposomal Bupivacaine in Adductor Canal Block for Knee Joint Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients undergoing elective general anesthesia for unilateral knee joint surgery
- Patients who provide informed consent
- Aged between 18 and 65 years old, regardless of gender
- American Society of Anesthesiologists (ASA) physical status classification of to
- Body mass index (BMI) 35 kg/m
You will not qualify if you...
- Femoral neuropathy
- Coagulation dysfunction
- Allergy to local anesthetics
- Infection at the puncture site
- History of chronic pain or opioid use
- Pregnancy
- Diabetes mellitus and peripheral neuropathy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Nanjing First Hospital
Nanjing, Jiangsu, China, 210006
Actively Recruiting
Research Team
L
Liu Han
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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