Actively Recruiting
Determination of the Prevalence of Unrecognized Heart Failure Among Patients at Risk in Urban Areas Across Germany Using CMR
Led by German Heart Institute · Updated on 2026-04-01
600
Participants Needed
1
Research Sites
589 weeks
Total Duration
On this page
Sponsors
G
German Heart Institute
Lead Sponsor
A
AstraZeneca
Collaborating Sponsor
AI-Summary
What this Trial Is About
Heart failure (HF) in patients at risk is often overlooked, and when detected, there is a lack of early and effective preventive interventions. The WE-CARE-HF-CMR study, conducted in large cities/metropol areas in Germany ( \> 1.000.000 inhabitants), aims to close this gap by evaluating the feasibility of a mobile, telemedicinemonitored HF-screening approach combining cardiac magnetic resonance imaging (CMR), quality of life assessment and laboratory tests as key elements in asymptomatic patients at risk. WE-CARE-HF-CMR will provide a proposal for a comprehensive, contemporary screening approach for patients at risk to develop HF tailored to the needs of the target population. This will provide important new information on the prevalence of asymptomatic HF in at-risk patients in urban versus rural areas. The results of the study will be compared with the results from the "HERZCheck'' trial, which provides data from approximately 4,500 participants in rural areas in Germany and has already been completed (NCT05122793).
CONDITIONS
Official Title
Determination of the Prevalence of Unrecognized Heart Failure Among Patients at Risk in Urban Areas Across Germany Using CMR
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Asymptomatic adults aged 40 to 69 years
- Chronic diabetes mellitus diagnosed, treated, or with elevated HbA1C
- Renal impairment diagnosed or laboratory evidence of chronic kidney disease stage III or higher
- Hypertension diagnosed or under treatment
- Hypercholesterolaemia diagnosed or under treatment
- Obesity with BMI over 30 kg/m²
- Current or former smoker or under treatment for smoking
- Female, male, or diverse gender
- Ability and willingness to provide informed consent
You will not qualify if you...
- Unable to provide written informed consent
- Diagnosed heart failure or previously detected reduced ejection fraction
- Standard MRI exclusion criteria (e.g., pacemaker, defibrillator, aneurysm clips, metallic foreign bodies in eyes)
- Any MRI exclusion criteria determined by the MRI laboratory
- Haemodynamically unstable (heart rate below 45/min, systolic blood pressure below 90 mmHg)
- Claustrophobia preventing MRI
- Sensorineural hearing loss of 30 dB or more with tinnitus
- Acute mental disorders requiring therapy
- Pregnant women
AI-Screening
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Trial Site Locations
Total: 1 location
1
Deutsches Herzzentrum der Charité
Berlin, Germany, 13353
Actively Recruiting
Research Team
P
Prof. Dr. Sebastian Kelle
CONTACT
D
Dr. Gisela Thiede
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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