Actively Recruiting
To Determine Whether it is Feasible to Treat Patients Requiring Urgent Radiotherapy Diagnosed With Metastatic Cord Compression (MSCC) on the Magnetic Resonance Linear Accelerator (MRL) in a Single Appointment and Compare it to the Standard of Care Radiotherapy Pathway
Led by The Christie NHS Foundation Trust · Updated on 2025-12-02
72
Participants Needed
1
Research Sites
156 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to understand whether the Magnetic Resonance Linear Accelerator (MRL) could expedite Radiotherapy treatment for Metastatic Cord Compression (MSCC) by removing the need for a planning CT (pCT) scan prior to treatment. Radiotherapy will be delivered in one appointment on the MRL and compared to the standard of care of two appointments: a CT scan and a Radiotherapy appointment. The main questions it aims to answer are: * Can the MRL deliver successful treatment of MSCC in a single 1-hour appointment? * Can the MRL treat participants within 24 hours from the doctor's decision to treat? * Did it take less time from consent to completion of treatment when patients were treated on the MRL? * Do the questionnaire scores reflect satisfaction with treatment on the MRL? Researchers will compare treatment on the MRL in one appointment to a group receiving standard of care radiotherapy in two appointments. Participants in both groups will receive the same prescription of 8Gray (Gy) in one treatment (fraction) delivered with one posterior-anterior beam as per our department policies and national standards. Participants will be asked to complete an optional questionnaire prior to treatment to monitor the diversity of the study population. This questionnaire is anonymised, no personal data that could identify a participant is collected on this questionnaire. After treatment participants will be asked to complete an experience questionnaire, to assess treatment experience. Once the questionnaire is complete active participation in the trial is no longer needed, researchers will monitor participants notes for up to 12 months after treatment to record participant well being and function.
CONDITIONS
Official Title
To Determine Whether it is Feasible to Treat Patients Requiring Urgent Radiotherapy Diagnosed With Metastatic Cord Compression (MSCC) on the Magnetic Resonance Linear Accelerator (MRL) in a Single Appointment and Compare it to the Standard of Care Radiotherapy Pathway
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Confirmed diagnosis of Metastatic Spinal Cord Compression (MSCC)
- Referred for an 8Gy, single fraction of radiotherapy
- 18 years or older
- Able to give informed consent in writing or verbally
- Willing to complete patient experience questionnaire
- Willing to have the research team review their case notes for up to 1 year following treatment
You will not qualify if you...
- Cannot give informed consent
- Any significant clinical disorder or lab finding making participation undesirable
- Unwilling to allow researchers to access clinical notes and diagnostic scans
- Unwilling to complete an experience questionnaire
- Cannot speak or understand English
- Contraindications to MRI identified after MRI safety screening (MRL arm only)
- Unable to tolerate MRI scanning (MRL arm only)
- Uncontrolled or poorly controlled pain (MRL arm only)
- MSCC in the cervical spine (MRL arm only)
- More than one vertebral level of compression (MRL arm only)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
The Christie NHS Foundation Trust
Manchester, United Kingdom, M20 4BX
Actively Recruiting
Research Team
C
Clinical Trial Radiographer
CONTACT
A
Alice Greenwood-Wilson
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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