Actively Recruiting
Determining the Benefits of Exercise on Cardiovascular Risk in PTSD
Led by Massachusetts General Hospital · Updated on 2025-12-02
10
Participants Needed
1
Research Sites
104 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to use a non-invasive imaging technique called positron emission tomography/magnetic resonance imaging (PET/MRI) to investigate the effects of exercise on brain activity and arterial (blood vessel) inflammation in people with PTSD symptoms and evidence of or elevated risk for artery disease.
CONDITIONS
Official Title
Determining the Benefits of Exercise on Cardiovascular Risk in PTSD
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18-65 years
- Trauma exposure
- PTSD symptoms
- Subclinical or clinical atherosclerotic cardiovascular disease, or increased risk for atherosclerotic cardiovascular disease (more than 2 of hypertension, diabetes, high cholesterol, or active smoking)
- Ability to understand and sign informed consent
You will not qualify if you...
- History of stroke, brain surgery, or seizure
- Use of certain cardiovascular medications such as beta-blockers, high-intensity statins, or PCSK-9 inhibitors
- Change in psychiatric or cardiovascular medication within the past 4 weeks
- Unstable blood pressure or cardiac arrhythmia
- Currently in a supervised or graduated exercise program
- Neurological or systemic inflammatory diseases or current anti-inflammatory therapy
- Moderate to severe alcohol or substance use disorder
- Current mania or psychosis
- Weight over 300 pounds
- Claustrophobia
- Pregnancy
- Metal implants
- Uncontrolled high blood sugar (HgbA1c over 7.5%)
- Significant radiation exposure from research procedures within the last 12 months
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114
Actively Recruiting
Research Team
A
Antonia Seligowski, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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