Actively Recruiting

Phase Not Applicable
Age: 18Years - 50Years
FEMALE
NCT06896799

Determining the Effect of Food Ordering on Blood Glucose In Gestational Diabetes Mellitus (DEFI-GDM)

Led by Queen's University, Belfast · Updated on 2026-04-17

35

Participants Needed

1

Research Sites

59 weeks

Total Duration

On this page

Sponsors

Q

Queen's University, Belfast

Lead Sponsor

I

Imperial College London

Collaborating Sponsor

AI-Summary

What this Trial Is About

The goal of this clinical trial is to determine whether the sequence of macronutrient consumption affects post-prandial glycaemia in women with gestational diabetes mellitus. The main questions it aims to answer are: * The difference in the magnitude of postprandial rise in blood glucose between the two test meals. * The difference in the magnitude of postprandial change in serum levels of gut hormones between the two test meals. * The difference in mean change in pre-post ingestion satiety scores between the two test meals. * The difference in 24 hour energy and macronutrient intake following the two test meals. Participants will attend two study visits at the Centre for Public Health, with an interval of at least two days between the visits and complete the following, anthropometric measurements, demographic and appetite questionnaires, glucose measurements, two food diaries and fasting blood samples and the consumption of the study breakfast. Participants will be asked to eat either the protein/fat-based component of the meal (scrambled egg) before or after the carbohydrate-based component (wholemeal toast) on their first visit and on the other visit they will be asked to eat the meal in the reverse order. The order in which this occurs will be randomised and each participant will act as their own control. Researchers will compare the results from participants between the two test meals to see if the order of macronutrient consumption has any effect on post-prandial glycaemia, gut hormones, satiety scores and energy and macronutrient intake.

CONDITIONS

Official Title

Determining the Effect of Food Ordering on Blood Glucose In Gestational Diabetes Mellitus (DEFI-GDM)

Who Can Participate

Age: 18Years - 50Years
FEMALE

Eligibility Criteria

Eligible

You may qualify if you...

  • Pregnant women with gestational diabetes mellitus
  • Aged 18 to 50 years old
Not Eligible

You will not qualify if you...

  • History of type 1 or type 2 diabetes mellitus
  • Dietary restrictions or clinically confirmed food allergies affecting study requirements
  • Taking medication for gestational diabetes at study entry
  • Severe nausea and vomiting (hyperemesis gravidarum) at study entry
  • Using anti-sickness medication (e.g., dimenhydrinate, prochlorperazine, promethazine)
  • Any medical condition limiting ability to complete study requirements

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Trial Site Locations

Total: 1 location

1

Centre for Public Health, Institute of Clinical Sciences A

Belfast, United Kingdom, BT12 6BA

Actively Recruiting

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Research Team

H

Hannah O'Hara, MBBS BSc PhD DFSRH MRCGP

CONTACT

D

Danielle Logan, PhD

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

CROSSOVER

Primary Purpose

OTHER

Number of Arms

2

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