Actively Recruiting
Determining the Effects of Non-invasive Brain Stimulation to Improve Quadriceps Muscle Function After ACL Reconstruction
Led by Arcadia University · Updated on 2026-05-07
42
Participants Needed
1
Research Sites
142 weeks
Total Duration
On this page
Sponsors
A
Arcadia University
Lead Sponsor
E
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Collaborating Sponsor
AI-Summary
What this Trial Is About
After knee surgery for a torn ACL, many women struggle with weak thigh muscles for years, partly due to reduced brain signals to these muscles. Our research tests a new approach to improve recovery by using low-level brain stimulation to boost these signals. The investigators will study 42 women, aged 18-35, who had ACL surgery. They'll be split into two groups: one receiving real brain stimulation and another getting a placebo, both during thigh-strengthening exercises. Over six sessions, the investigators measure thigh muscle strength, speed, and steadiness, plus two brain signal measures, using special equipment. The investigators will also check if stronger brain signals lead to better muscle performance, especially in women. Our goal is to show that this new method strengthens thigh muscles better than standard rehab, helping women recover better after surgery. If successful, this could improve physical therapy for women recovering from ACL surgery, making daily activities and return to sport easier.
CONDITIONS
Official Title
Determining the Effects of Non-invasive Brain Stimulation to Improve Quadriceps Muscle Function After ACL Reconstruction
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Female participants 2 to 6 months after ACL reconstruction surgery
You will not qualify if you...
- Multiple ligament reconstruction
- Osteochondral procedures
- Any previous lower extremity surgery
- Previous ACL injury
- Metal or implants in the head or neck
- History of neurological disease
- Seizures
- Severe migraines
- Concussion within the last 6 months
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Ryan Zarzycki
Glenside, Pennsylvania, United States, 19038
Actively Recruiting
Research Team
R
Ryan Zarzycki, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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