Actively Recruiting
Determining Elements of Anti-Fungal Immunity in BURN Patients
Led by Assistance Publique - Hôpitaux de Paris · Updated on 2026-04-23
327
Participants Needed
1
Research Sites
287 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Scientific justification Invasive fungal diseases (IFDs) pose a substantial threat, especially in immunocompromised patients, necessitating urgent research focus and therapeutic advancements. The IFI-BURN study, involving a cohort of patients with severe burn injury (n=276), revealed a significant IFD incidence of 31.6% and underscored their critical impact on morbidity and mortality. While fungi are present everywhere, for moulds within the environment and for yeasts within our microbiota, why certain patients develop IFDs and others do not, remains poorly understood. The answer most likely resides in the impact of the burn injury on the immune response, loss of skin barrier and particular predisposing immune phenotype of patients. The immune system is composed of both cellular and humoral components, but the latter is far less studied in antifungal immunity although they exert multiple antimicrobial mechanisms.
CONDITIONS
Official Title
Determining Elements of Anti-Fungal Immunity in BURN Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients 18 years or older
- Admission less than 4 days following burn injury
- Total burn surface area 15% or more
- No opposition from the patient or relatives to participate
- Affiliation to social security or any health insurance
You will not qualify if you...
- Pregnancy
- Opposition from the patient or relatives to participate
- Decision not to resuscitate or to limit or stop active therapies
AI-Screening
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Trial Site Locations
Total: 1 location
1
Hôpital Saint Louis AP-HP
Paris, France
Actively Recruiting
Research Team
E
Emmanuel Dudoignon, MD
CONTACT
J
Jérôme Lambert, MD PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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