Actively Recruiting
Determining Elements of Anti-Fungal Immunity in Burn Patients
Led by Assistance Publique - Hôpitaux de Paris · Updated on 2026-04-23
327
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Invasive fungal diseases (IFDs) are a serious risk, especially for people with weakened immune systems. This research focuses on adults with severe burn injuries, as a previous study showed that about 31.6% of such patients developed IFDs, which greatly impact health and survival. The study aims to understand why some burn patients develop these infections while others do not, looking particularly at how burn injuries affect immune responses and skin barriers. This observational study involves adult burn patients who have experienced significant burns covering at least 15% of their body surface area and were admitted within 4 days of injury. Researchers will collect biological samples, including blood, rectal swabs, and skin swabs from burned areas, at multiple times: day 0, 3, 7, 14, and 21. These samples will help study the body's antifungal immune response and its role in infection development. Participants will be followed during their hospital stay for up to 18 months. Researchers will monitor the onset of invasive fungal disease, survival at 30 and 90 days, organ failure, severity scores, days without kidney or ventilation support, and length of ICU and hospital stays. The study involves regular biological sampling and clinical assessments to track immune status and health outcomes related to fungal infections in burn patients.
CONDITIONS
Brief Title
Determining Elements of Anti-Fungal Immunity in BURN Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients 18 years or older
- Admission to hospital less than 4 days after burn injury
- Total burn surface area 15% or greater
- Patient or relatives do not oppose participation
- Affiliated with social security or any health insurance
You will not qualify if you...
- Pregnancy
- Opposition to participation by patient or relatives
- Decision not to resuscitate or to limit or stop active therapies
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Up to 21 days
Participants provide biological samples including blood and swabs at multiple timepoints after burn injury to study anti-fungal immunity.
5 visits (in-person) on days 0, 3, 7, 14, and 21
Duration - Up to 18 months
Participants are observed for the onset of invasive fungal disease and other health outcomes during their hospital stay and up to 18 months.
Trial Site Locations
Total: 1 location
1
Hôpital Saint Louis AP-HP
Paris, France
Actively Recruiting
Research Team
E
Emmanuel Dudoignon, MD
J
Jérôme Lambert, MD PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here