Studying Immune Responses Against Fungal Infections in Adult Patients With Severe Burns

What this Trial Is About

Invasive fungal diseases IFDs are a serious risk, especially for people with weakened immune systems. This research focuses on adults with severe burn injuries, as a previous study showed that about 31.6% of such patients developed IFDs, which greatly impact health and survival. The study aims to understand why some burn patients develop these infections while others do not, looking particularly at how burn injuries affect immune responses and skin barriers. This observational study involves adult burn patients who have experienced significant burns covering at least 15% of their body surface area and were admitted within 4 days of injury. Researchers will collect biological samples, including blood, rectal swabs, and skin swabs from burned areas, at multiple times day 0, 3, 7, 14, and 21. These samples will help study the bodys antifungal immune response and its role in infection development. Participants will be followed during their hospital stay for up to 18 months. Researchers will monitor the onset of invasive fungal disease, survival at 30 and 90 days, organ failure, severity scores, days without kidney or ventilation support, and length of ICU and hospital stays. The study involves regular biological sampling and clinical assessments to track immune status and health outcomes related to fungal infections in burn patients.

Determining Elements of Anti-Fungal Immunity in BURN Patients