Establishing Normal Hormone Levels in Children and Teens Using Mass Spectrometry

What this Trial Is About

Researchers are conducting a study to establish usual hormone level values in children and adolescents up to 20 years old using liquid chromatography coupled with mass spectrometry LC-MSMS. This method allows for precise hormone measurements from small blood samples and aims to improve upon older immunoassay techniques that have limitations and safety concerns. The study is prospective, multicenter, and observational, focusing on healthy individuals without endocrine or acute inflammatory conditions. Participants will have an additional blood sample taken during a routine follow-up blood draw at hospital consultations within the Assistance Publique - Hpitaux de Paris network. The extra blood volume will be carefully limited based on weight, with a maximum of 2.7 mL collected. The samples will be analyzed by mass spectrometry at specialized clinical metabolomics laboratories under expert supervision. During the study, securely pseudonymized data including age, gender, pubertal stage, and hormone test results will be recorded in a confidential database. Samples and data will be stored securely for up to 15 years following the research phase. The primary goal is to determine normal hormone values in the pediatric population over a one-week measurement period. This research will help improve hormone assay reliability and patient management in clinical practice.

Determining Paediatric Usual Values for Hormones Dosages by LC-MS/MS