Actively Recruiting
Determining the Role of Social Reward Learning in Social Anhedonia
Led by University of Alabama at Birmingham · Updated on 2025-07-24
152
Participants Needed
2
Research Sites
228 weeks
Total Duration
On this page
Sponsors
U
University of Alabama at Birmingham
Lead Sponsor
U
University of California, Los Angeles
Collaborating Sponsor
AI-Summary
What this Trial Is About
This is a clinical trial study that aims to evaluate the specificity of the relationship between reduced sensitivity to social reward and social anhedonia at both behavioral and neural levels. Individuals who recently experienced their first-episode psychosis will be recruited. Participants will be randomized 1:1 to motivational interviewing or a time- and format-matched control probe. At pre- and post-probe, participants will perform two social reward learning tasks in the scanner. With this design feature, we will examine the relationship between sensitivity to social reward and reduced subjective experience of social pleasure at both the behavioral and neural levels.
CONDITIONS
Official Title
Determining the Role of Social Reward Learning in Social Anhedonia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18-35 years
- First episode of a psychotic illness that began within the past three years
- DSM-5 diagnosis of schizophrenia, schizophreniform, or schizoaffective disorder
- Currently taking second-generation antipsychotic medications
- Estimated premorbid IQ of at least 70 as assessed by the Wechsler Test of Adult Reading
- Suitable for MRI scanning and willing to participate in scanning procedures
- Sufficient fluency in English to understand testing procedures
- Corrected vision of at least 20/30
You will not qualify if you...
- No evidence that substance use causes the psychosis diagnosis to be unclear (no substance-induced psychosis)
- No moderate or severe alcohol or substance use disorder in the past 3 months
- No significant medical conditions such as epilepsy or major head injury
- For females, not currently pregnant
- No use of sedatives or anxiolytics on the day of assessment
- No changes in medication within 3 weeks before enrollment
AI-Screening
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Trial Site Locations
Total: 2 locations
1
University of Alabama at Birmingham
Birmingham, Alabama, United States, 35294
Actively Recruiting
2
University of California Los Angeles
Los Angeles, California, United States, 90095
Actively Recruiting
Research Team
J
Junghee Lee, PhD
CONTACT
A
Andrew Meddaugh, BA
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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