Evaluating Juvenile and Biobank Tissue Cells to Develop New Therapies for Cartilage and Bone Injuries and Osteoarthritis

What this Trial Is About

Researchers are studying cells from tissues of juvenile patients and bio-banked cartilage to develop new treatments for cartilage and bone injuries and osteoarthritis. The study aims to find out which tissue sourcepolydactyly digit, iliac apophysis, or other bio-banked cartilageproduces better cartilage both in laboratory conditions and in living organisms. This observational study is conducted by clinicians and scientists experienced in cell-based therapies for cartilage and bone repair. Participants undergoing surgery for polydactyly will donate the waste tissue from digit amputation, and those having surgery for hip dislocation will provide a small piece of cartilage from the iliac apophysis. Additional tissues come from biobanks and the NHS Blood and Transplant service. The study focuses on evaluating cells from bone, bone marrow, cartilage, and possibly skin and fat, to assess their potential for musculoskeletal repair and allogenic cell therapy development. Participants provide tissue samples during their routine surgeries, with no additional interventions. Researchers assess cell viability up to 48 hours after collection and measure cartilage components such as glycosaminoglycan content over three months. The study involves analyzing these cells to better understand their potential for treating osteoarthritis and related injuries, with long-term monitoring planned until 2037.

Developing Allogeneic Musculoskeletal Therapies