Actively Recruiting
Developing Brain Imaging Analysis Expertise for Personalizing Transcranial Electric Stimulation in Anhedonia Treatment of Patients With Bipolar Depression
Led by The University of Texas Health Science Center, Houston · Updated on 2026-02-18
45
Participants Needed
1
Research Sites
216 weeks
Total Duration
On this page
Sponsors
T
The University of Texas Health Science Center, Houston
Lead Sponsor
M
Milken Institute
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this study is to investigate whether transcranial direct-current stimulation (tDCS) will engage reward-related brain circuitry, more specifically the uncinate fasciculus (UF) tract, which connects the orbitofrontal cortex (OFC) and nucleus accumbens (NAcc) regions. Also to evaluate whether the changes in the fractional anisotropy (FA) of the UF tract are associated with changes of clinical symptoms of anhedonia and finally to investigate the moderation role of simulated electric fields (EFs) in an association between FA of the UF and symptoms of anhedonia.
CONDITIONS
Official Title
Developing Brain Imaging Analysis Expertise for Personalizing Transcranial Electric Stimulation in Anhedonia Treatment of Patients With Bipolar Depression
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of Bipolar Disorder and clinically significant anhedonia
- Mild symptoms of depression
You will not qualify if you...
- Substance abuse or dependence and any drug use (except alcohol or nicotine) in the past month before baseline
- Personality disorder interfering with study participation as judged clinically
- Previous neurological conditions such as epilepsy, traumatic brain injury, or stroke
- Severe, life-threatening non-psychiatric medical conditions
- Specific contraindications for tDCS like metallic plates in the head
- Participants identified as acutely suicidal or severely agitated
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
The University of Texas Health Science Center at Houston
Houston, Texas, United States, 77030
Actively Recruiting
Research Team
J
Jair C Soares, MD,PhD
CONTACT
A
Alexandre P Diaz, MD,PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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