Compulsivity and impulsivity traits linked to attenuated developmental frontostriatal myelination trajectories.
Gabriel Ziegler, Tobias U Hauser, Michael Moutoussis...
https://pubmed.ncbi.nlm.nih.gov/31086316Actively Recruiting
Age: 6Years - 80Years
All Genders
ID04631042
An Observational Study of the Developing Brain, Impulsivity and Compulsivity
Led by National Institute of Mental Health (NIMH) · Updated on 2026-04-13
1100
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating how impulsivity and compulsivity, behaviors that vary among individuals and can be linked to mental disorders, relate to brain development and genetics. This observational study aims to understand how these behaviors affect brain features like cortical glutamate levels and brain connectivity, and how genetics contribute to these brain changes. The study focuses on a wide age range from 6 to 80 years, including twins to assess heritability. Participants will undergo detailed assessments including medical history reviews, interviews about mental and behavioral development, and surveys on impulsivity and compulsivity. They may complete cognitive tests and provide blood or saliva samples for genetic analysis, including creating stem cells. Brain imaging using magnetic resonance imaging (MRI) will capture brain structure and function. Some participants, especially those under 25, may be invited to repeat tests every 1-2 years. During the study, participants may be asked to provide photographs of their face and irises and may involve family members, particularly twins. The research team measures changes in brain glutamate levels and connectivity, assesses genetic influence, and monitors behavioral symptoms. For participants over 25, the study lasts less than one month, while younger participants may have longer follow-up. Safety and capacity to participate are carefully evaluated throughout.
CONDITIONS
Brief Title
Developing Brain, Impulsivity and Compulsivity
Who Can Participate
Age: 6Years - 80Years
All Genders
Eligibility Criteria
You may qualify if you...
- Willingness to comply with all study procedures and availability for the study duration
- Age between 6 and 80 years
- Ability to understand and willingness to sign a written informed consent form
You will not qualify if you...
- Cognitive inability to perform study procedures or provide informed consent, including full-scale IQ under 70 or intellectual disability history
- Very premature birth before 32 weeks of gestational age
- Known brain abnormalities or medical conditions affecting brain anatomy such as tumor, epilepsy, stroke, or head injury with loss of consciousness over one hour
- Diagnosis of psychotic disorders including schizophrenia or unspecified psychosis
- Dementia or other conditions that may impede study compliance or completion
- Pregnancy
- Any medical or psychiatric condition that may confound study data or assessments
- Inability to undergo MRI due to metal implants, claustrophobia, inability to lie flat, pregnancy, or other MRI contraindications according to safety guidelines if participating in MRI procedures
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Diagnostic Evaluation
Duration - Baseline
Participants undergo clinical assessments including clinician-led interviews, neurobehavioral assessments, neuroimaging, and genomic sample collection to evaluate impulsivity, compulsivity, and brain features.
1 visit (in-person)
Long-term Monitoring
Duration - Up to 10 years
Participants are followed over time with yearly assessments to monitor changes in brain glutamate levels, structural and functional connectivity, and neurodevelopmental markers.
Yearly visits (in-person)
Trial Site Locations
Total: 1 location
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
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Research Team
T
Tonya J White, M.D.
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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Published Research Related To This Trial
Fronto-striatal glutamatergic compounds in compulsive and impulsive syndromes: a review of magnetic resonance spectroscopy studies.
Jilly Naaijen, David J Lythgoe, Houshang Amiri...
https://pubmed.ncbi.nlm.nih.gov/25712432New developments in human neurocognition: clinical, genetic, and brain imaging correlates of impulsivity and compulsivity.
Naomi A Fineberg, Samuel R Chamberlain, Anna E Goudriaan...
https://pubmed.ncbi.nlm.nih.gov/24512640