Actively Recruiting
Developing a Complex ex Vivo Endometrial Tissue Model to Improve Endometriosis Care
Led by Hospices Civils de Lyon · Updated on 2026-01-30
90
Participants Needed
2
Research Sites
195 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Endometriosis is a chronic gynaecological disease characterised by the growth of endometrium outside the uterus. It affects 10% of childbearing age women. There is no cure for endometriosis. Hormonal treatments should be the first line therapy. The benefit-risk ratio of symptomatic treatment with hormone therapy varies greatly from one woman to another. The pathophysiology of endometriosis and the mechanisms of action of these treatments are still poorly understood. This may be due to the lack of an optimal experimental model for studying the disease. The aim of this project is to develop a complex ex vivo endometrial model recapitulating the organisation and properties of the human endometrium using innovative tissue bioengineering methods. This model will make it possible to develop a pre-clinical approach that predicts individual response to different types of hormonal treatment in order to optimise therapeutic choices and provide a better understanding of the effects of these treatments.
CONDITIONS
Official Title
Developing a Complex ex Vivo Endometrial Tissue Model to Improve Endometriosis Care
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Female
- Aged between 18 and 50 years
- Has used or is using hormonal contraceptive treatment
- Has given written consent to participate
- Diagnosed with a benign gynecological condition not affecting the endometrium and scheduled for hysterectomy, hysteroscopy, or laparoscopy, or diagnosed with endometriosis and scheduled for laparoscopy or hysterectomy
- Affiliated with the French social security system
You will not qualify if you...
- Pregnant at the time of sampling or within 3 months prior to sampling
- Currently breastfeeding
- Undergoing physiological menopause
- Received hormonal treatment with non-steroid hormones in the 3 months prior to sampling
- Using a non-hormonal contraceptive intrauterine device (copper coil)
- Personal history of cancer of the breast, ovary, endometrium, or cervix
- Diagnosed with Lynch syndrome
- Under legal protection (guardianship or curatorship)
- Deprived of liberty by judicial or administrative decision
- Body mass index (BMI) less than 18.5 or greater than 30
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Trial Site Locations
Total: 2 locations
1
Hôpital Femme Mère Enfant / GHE
Bron, France, 69500
Actively Recruiting
2
Hôpital de la Croix-Rousse / GHN
Lyon, France, 69004
Actively Recruiting
Research Team
C
Charles-André PHILIP, M.D., PhD
CONTACT
A
Axelle BRULPORT, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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