Using Hyperpolarized Gas MRI and Bronchoscopy to Detect Early Lung Transplant Rejection and Immune Changes

What this Trial Is About

Researchers are studying lung transplant recipients to improve early detection and management of Acute Cellular Rejection ACR, which is a major risk factor for chronic lung transplant failure and death. The study evaluates how Hyperpolarized Gas Magnetic Resonance Imaging HGMRI can identify early lung changes associated with ACR. It also examines how these imaging findings relate to immune system activity by analyzing single-cell RNA from lung samples. Participants undergo a series of procedures including two HGMRI scans and two navigational bronchoscopies. These tests help detect regional lung dysfunction and guide targeted tissue sampling during bronchoscopy for better diagnosis. The study includes a baseline visit and a one-year follow-up to observe how lung changes progress and correspond to clinical ACR diagnoses. During the study, participants will provide blood and urine samples, complete pulmonary function tests, and undergo imaging and tissue analysis. Researchers measure ventilation defects, lung gas exchange, immune cell gene activity, and lung function over time. The study aims to enhance the accuracy of ACR detection and improve monitoring of lung transplant health over a 24-month period after transplant surgery.

Developing Hyperpolarized Gas MRI Signatures to Detect and Manage Acute Cellular Rejection