Actively Recruiting
Developing Metagenomic Approaches to Identify the Causes of Pediatric Infectious Diseases
Led by Children's Hospital of Fudan University · Updated on 2024-05-13
1000
Participants Needed
1
Research Sites
312 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Infectious diseases remain leading causes of mortality and morbidity in children. Rapid and accurate diagnosis of infectious diseases in children is important for developing an effective treatment and management strategy. However, the current diagnosis of infectious agents mainly depends on culture and molecular testing. Both of the methods either has long turnaround times or narrow detection range. Metagenome next generation sequencing (mNGS) has been applied to the diagnosis of central nervous system infection, lower respiratory tract infection and sepsis, which showed high positive rate, short turnaround time. However, there is currently no assessment of the diagnostic efficacy of mNGS in children infectious diseases. This study used the DNA extraction and library construction technology developed for children's low volume clinical samples to assess the sensitivity and specificity of mNGS in the diagnosis of infectious diseases, and the treatment outcome based on mNGS test results.
CONDITIONS
Official Title
Developing Metagenomic Approaches to Identify the Causes of Pediatric Infectious Diseases
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients are highly suspected of sepsis
- Patients are highly suspected of respiratory infections
- Patients are highly suspected of central nervous system infection
- Patients are highly suspected of fever of unknown origin
You will not qualify if you...
- Congenital malformations
- Patients requiring surgical intervention
- Patients with skin barrier dysfunction
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Children Hospital of Fudan University
Shanghai, Shanghai Municipality, China, 201102
Actively Recruiting
Research Team
W
Wenhao Zhou, Doctor
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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