Actively Recruiting
Developing a Novel Human Laboratory Paradigm for AUD Medication Screening
Led by Yale University · Updated on 2025-07-29
90
Participants Needed
1
Research Sites
86 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The intent of the study is to develop two versions of the 'ability to resist' drinking model designed to screen Alcohol Use Disorder (AUD) medications.
CONDITIONS
Official Title
Developing a Novel Human Laboratory Paradigm for AUD Medication Screening
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Signed and dated informed consent form provided
- Male or female aged 21 to 65
- Able to read and write English
- Meets DSM-5 criteria for Alcohol Use Disorder within the past 6 months
- For males: drinks more than 28 drinks per week and exceeds 4 drinks per day at least once per week
- For females: drinks more than 14 drinks per week and exceeds 3 drinks per day at least once per week
- Drinking criteria must be met during the 30-day period prior to study baseline
- Laboratory sessions scheduled to avoid major responsibilities the following day that might limit drinking (e.g., job interview, exam)
You will not qualify if you...
- Significant current medical conditions including neurological, cardiovascular, endocrine, thyroid, renal, liver diseases, seizures, delirium, hallucinations, or HIV
- Current DSM-5 substance use disorder other than Alcohol Use Disorder, tobacco use disorder, or mild cannabis dependence
- Positive urine drug screen for illicit drugs at intake
- Women who are pregnant, nursing, or not using approved birth control methods unless surgically sterile or postmenopausal
- Suicidal, homicidal, or current diagnosis within past 6 months of schizophrenia, bipolar disorder, or psychosis
- More than one member from the same household participating
- History of clinically significant alcohol withdrawal symptoms or high withdrawal assessment scores
- Currently in treatment for drinking or attempted to quit drinking in past 3 months
- Use of any investigational drug within 4 weeks before intake
- Participation in other studies involving excessive blood sampling or interventions within past 8 weeks
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Yale University
New Haven, Connecticut, United States, 06510
Actively Recruiting
Research Team
M
Meaghan Lavery
CONTACT
S
Sabrina Coppola
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
OTHER
Number of Arms
2
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