Actively Recruiting
Development of 3D Multi-Parametric Ultrasound (MPUS) as a Decision Support Tool for Patients With Abdominal and Pelvic Tumors Undergoing Therapy
Led by University of California, San Diego · Updated on 2026-01-26
80
Participants Needed
3
Research Sites
52 weeks
Total Duration
On this page
Sponsors
U
University of California, San Diego
Lead Sponsor
N
National Cancer Institute (NCI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are evaluating how 3-dimensional multi-parametric ultrasound (3D MPUS) imaging can support decisions for patients with liver tumors undergoing therapy. This observational study focuses on continuous and dynamic imaging to monitor early treatment responses. 3D-MPUS offers a potentially safe and affordable way to provide detailed functional and tissue information alongside standard imaging and blood tests. Participants will undergo a 3D-MPUS imaging session involving an injection of sulfur hexafluoride intravenously, followed by about 20 minutes of ultrasound scanning to locate lesions and collect imaging data. This diagnostic test aims to capture detailed images of liver tumors to assist in assessing therapy effects. The study includes only one imaging procedure per participant. During the study, participants will receive the ultrasound scan and contrast agent. Researchers will evaluate the diagnostic value of the 3D-MPUS data collected during this baseline visit. Participants will be monitored to ensure safety and compliance with the protocol. The study is sponsored by the University of California, San Diego, and participation involves a single imaging visit with no long-term follow-up mentioned.
CONDITIONS
Brief Title
Development of 3D Multi-Parametric Ultrasound (MPUS) as a Decision Support Tool for Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participant has untreated liver metastases from colorectal low-grade adenocarcinoma confirmed by biopsy or imaging and plans to start a new cancer therapy.
- Participant is 18 years of age or older.
- Participant has at least one liver tumor lesion 1 cm or larger and up to 14 cm suitable for ultrasound imaging.
- Participant agrees to follow the study protocol.
- Participant has provided written informed consent to join the study.
You will not qualify if you...
- Participant has had a severe allergic reaction to ultrasound contrast media or polyethylene glycol (PEG).
- Participant has a medical condition that could prevent participation, as judged by the treating doctor or study director.
- Participant is pregnant or breastfeeding.
- Participant has a cardiac shunt or pulmonary hypertension, which are contraindications for ultrasound contrast agents.
- Participant has kidney problems with creatinine levels above 1.5 mg/dl, which contraindicates CT imaging.
AI-Screening
AI-Powered Screening
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Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Approximately 20 minutes per imaging session
Participants undergo 3D multi-parametric ultrasound imaging to help monitor their liver tumors during therapy.
1 baseline imaging visit with possible additional imaging during therapy
Duration - Throughout the course of therapy
Participants are observed over time to assess early-phase treatment response using imaging data.
Follow-up imaging visits as scheduled during therapy
Trial Site Locations
Total: 3 locations
1
Stanford University, School of Medicine
Palo Alto, California, United States, 94305
Actively Recruiting
2
University of California, San Diego
San Diego, California, United States, 92037
Actively Recruiting
3
Thomas Jefferson Hospital
Philadelphia, Pennsylvania, United States, 19107
Actively Recruiting
Research Team
D
David Marcellus, BS
S
Suzanna Lee
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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