Actively Recruiting
Development and Application of Accurate Detection Technology Based on Multimodal Data of Breast Cancer Comobid Depression
Led by Xiangya Hospital of Central South University · Updated on 2025-04-22
1000
Participants Needed
1
Research Sites
107 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study is a prospective, observational clinical research aimed at establishing a multimodal database encompassing clinical information and gut microbiome data from a sample of over 1,000 breast cancer patients comorbid with depression. The research involves collecting cohort sample information from breast cancer patients with comorbid depression, as well as fecal, blood, and saliva specimens for metagenomic sequencing, untargeted metabolite detection, and cortisol level analysis, respectively. Based on the collected multimodal data, diagnostic, efficacy prediction, and prognostic survival prediction models for breast cancer with comorbid depression will be developed. Additionally, a precision prediction cloud platform will be designed and deployed to support data upload, model prediction, and result visualization.
CONDITIONS
Official Title
Development and Application of Accurate Detection Technology Based on Multimodal Data of Breast Cancer Comobid Depression
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Pathologically confirmed primary breast cancer
- Age between 18 and 80 years
- No previous history of cancer except breast cancer
- Aware of breast cancer diagnosis
- Karnofsky Performance Status (KPS) score greater than 70
- Willing to provide blood, fecal, and saliva samples and sign informed consent
You will not qualify if you...
- Diagnosed mental disorders before or after breast cancer diagnosis
- Severe chronic diseases such as central nervous system disorders, severe head trauma, substance abuse, intellectual disability, diabetes, gynecological diseases, cardiovascular diseases, thyroid disorders
- Two or more primary cancers from different tissues
- Breast cancer with central nervous system metastasis
- Clinically diagnosed digestive system diseases like enteritis or gastritis
- Use of antidepressant or anxiolytic therapy during the study
- Use of medications affecting gut function or metabolism during the study
- Pregnant or lactating women
- Radiotherapy or chemotherapy in the last 21 days
- Use of antibiotics, probiotics, prebiotics, or synbiotics within 3 months before the study
- Other conditions deemed unsuitable by investigators
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Xiangya Hospital of Central South University
Changsha, Hunan, China, 410000
Actively Recruiting
Research Team
J
Jun Huang，doctor
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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