Actively Recruiting
Development, Application, and Mechanistic Investigation of a Novel Minimally-Invasive Bidirectional Epidural Cerebellar Stimulation Technique for Cerebellar Cognitive Affective Syndrome
Led by Peking University First Hospital · Updated on 2025-09-10
200
Participants Needed
1
Research Sites
152 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Building on previous findings regarding microglial immune function and the immunosuppressive effects of glucocorticoids, this project centers on the cerebellum's role in cognitive science. Using Cushing's syndrome-induced cerebellar atrophy leading to CCAS as a model, we aim to elucidate the pathogenic mechanisms governed by the neuro-adrenal-immune network and to uncover the molecular basis by which a novel minimally invasive brain-machine fusion system ameliorates cerebellar ataxia and cognitive impairment.
CONDITIONS
Official Title
Development, Application, and Mechanistic Investigation of a Novel Minimally-Invasive Bidirectional Epidural Cerebellar Stimulation Technique for Cerebellar Cognitive Affective Syndrome
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Clinically and biochemically confirmed ACTH-dependent or ACTH-independent Cushing syndrome
- Cranial MRI showing cerebellar atrophy with volume 1.5 SD below age norms
- Established clinical diagnosis of Cerebellar Cognitive Affective Syndrome (CCAS) with CCAS-S total score 20 or higher
- Cerebellar ataxia rating scale (SARATA) score of 10 or more indicating moderate motor ataxia
- Positive cognitive impairment screen with MoCA below 26 or Z-scores -1.5 or less in at least two cognitive areas
- Willingness to undergo minimally invasive epidural cerebellar stimulation and provide written informed consent
You will not qualify if you...
- Significant systemic disease
- Major complications or critical deviations in data or procedures
- Clinical deterioration, serious adverse events, or poor compliance making continued participation inappropriate
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Department of Urology, Peking University First Hospital, Beijing, 100034
Beijing, China
Actively Recruiting
Research Team
Z
Zheng Zhang
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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