Actively Recruiting
Development of a Battery of Audiological Tests for the Precision Diagnosis of Age-related Hearing Loss
Led by Institut Pasteur · Updated on 2025-03-03
700
Participants Needed
2
Research Sites
439 weeks
Total Duration
On this page
Sponsors
I
Institut Pasteur
Lead Sponsor
C
CEntre de Recherche et d'Innovation en Audiologie Humaine
Collaborating Sponsor
AI-Summary
What this Trial Is About
Age-related hearing loss, or presbycusis, is caused by many genetic and environmental factors. Its prevalence poses a public health challenge of early identification and effective hearing aid treatment. However, the lack of screening and of a validated audiological test battery to diagnose an individual's needs and to guide hearing aid adjustments is a major obstacle. Furthermore, monogenic forms of hearing loss affect only one functional module of hearing. The audiological test(s) dependent on the function of this module are affected, in a progressive manner, but not the others. A previous study showed that in early onset presbycusis patients, a quarter of the subjects tested were affected by monogenic presbycusis. The collection of audiological and vestibular tests, carried out on proven monogenic presbycusis patients and compared to that of normal hearing patients, would constitute a battery of tests allowing a precision diagnosis, then developed to all forms of presbycusis in order to study if the identification of abnormal functional modules can usefully guide the diagnosis and the early fitting.
CONDITIONS
Official Title
Development of a Battery of Audiological Tests for the Precision Diagnosis of Age-related Hearing Loss
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Be over the age of 18
- Be affiliated to a social security system
- Have a good command of the French language (oral and written)
- For participants with anticipated presbycusis: over 40 years old with a hearing aid recipient or coming for first hearing aid, or between 18 and 40 years old with a hearing aid recipient, coming for first hearing aid, or declare a progressive genetic birth defect
- For healthy volunteers: have no known hearing loss
You will not qualify if you...
- Report having been chronically exposed to loud sounds
- Have a history of ototoxic substances
- Have sequelae of ear infections and/or history of ENT disease that permanently affects hearing or balance
- Have an ethnic origin not covered in gene variant frequency data by the Pasteur Institute
- Have type II diabetes
- Have a neurological or psychiatric condition interfering with comprehension or ability to move
- Be under guardianship
- Be deprived of liberty by judicial or administrative decision or subject to legal protection
- Not be subject to a social security system
- Take narcotic substances, alcohol, or medication that diminishes cognitive abilities
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 2 locations
1
Laboratoire de correction auditive
Paris, France, 75001
Not Yet Recruiting
2
CEntre de Recherche et d'Innovation en Audiologie Humaine
Paris, France, 75012
Actively Recruiting
Research Team
C
Celine Quinsac
CONTACT
P
Paul Avan, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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