Actively Recruiting
Development of Computational Models to Predict the Short-, Medium- and Long-term Cartilage Degeneration and Pain for Patients With Early-stage Osteoarthritis or Anterior Cruciate Ligament Injury
Led by Aalborg University · Updated on 2025-08-21
105
Participants Needed
2
Research Sites
626 weeks
Total Duration
On this page
Sponsors
A
Aalborg University
Lead Sponsor
L
Lund University
Collaborating Sponsor
AI-Summary
What this Trial Is About
Knee osteoarthritis is a complex condition, and selecting effective non-drug treatments like orthoses or exercise is often difficult and imprecise. This study will follow individuals with early-stage knee osteoarthritis or previous anterior cruciate ligament injury to develop computational models that predict cartilage degeneration and pain over time. The models will integrate data from medical imaging, movement analysis, muscle strength testing, pain assessments, questionnaires, and biomarkers to improve personalized treatment planning.
CONDITIONS
Official Title
Development of Computational Models to Predict the Short-, Medium- and Long-term Cartilage Degeneration and Pain for Patients With Early-stage Osteoarthritis or Anterior Cruciate Ligament Injury
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults under 70 years old
- Signed informed consent form
- For ACL reconstruction group: ACL injury within the last year and planned for ACL reconstruction
- For ACL no reconstruction group: ACL injury within the last year with no plans for reconstruction
- For early to moderate knee osteoarthritis group: diagnosed knee osteoarthritis with Kellgren Lawrence grade 1, 2, or 3
- For control groups: no radiological changes on knee X-ray and no knee problems
You will not qualify if you...
- Previous knee surgery before current knee trauma
- Severe ischemic or neurological problems
- Body mass index above 32
- Clinically significant inflammatory or degenerative joint disease in joints other than the affected knee
- Unsuitable for MRI (e.g., pacemaker or claustrophobia)
- Thigh circumference larger than 73.5 cm or calf circumference larger than 61.5 cm preventing fitting MRI knee coil
- Drug addiction including cannabis, opioids, or other drugs as reported by the participant
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Aalborg University Hospital
Aalborg, North Denmark, Denmark, 9000
Actively Recruiting
2
Aalborg University
Aalborg, Northen Denmark, Denmark, 9220
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
6
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