Actively Recruiting
Development of FAPI PET as a Non-invasive Biomarker of Pulmonary Fibrogenesis
Led by University of Wisconsin, Madison · Updated on 2026-03-11
50
Participants Needed
1
Research Sites
93 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to gain more information about how fibroblast activation protein inhibitor (FAPI) binds to a certain type of cells in fibrotic lung tissue and how this information can be used to better diagnose and track fibrotic lung disease activity. Participants will undergo up to 4 PET/MRI scans using the FAPI radiotracer.
CONDITIONS
Official Title
Development of FAPI PET as a Non-invasive Biomarker of Pulmonary Fibrogenesis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Able and willing to provide informed consent
- Group A: Clinically evaluated for need to start new treatment, change current treatment, or add treatment for fibrotic hypersensitivity pneumonitis (HSP) or idiopathic pulmonary fibrosis (IPF)
- Group B: Clinically stable without need to start or change treatment for fibrotic HSP or IPF
- Crossover: Participants in Group B who later require new or changed treatment for fibrotic HSP or IPF
- Willing and able to undergo PET/MRI
- Participants may use mild oral anxiolytics if they have their own prescription, provide informed consent for use, and have a driver for the visit
You will not qualify if you...
- Unable or unwilling to provide informed consent
- Pregnant
- Contraindications to or inability to undergo PET/MRI
- Contraindications to gadolinium-based contrast agents (GBCA), such as severe kidney disease or previously documented low kidney function (GFR < 30 ml/min/1.73 m2)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Wisconsin - Madison
Madison, Wisconsin, United States, 53705
Actively Recruiting
Research Team
R
Radiology Studies
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
DIAGNOSTIC
Number of Arms
3
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