Improving Magnetic Resonance Spectroscopy for Brain and Muscle Metabolite Imaging in Healthy Adults Aged 18 to 65

What this Trial Is About

Researchers are working to improve and develop magnetic resonance imaging MRI and magnetic resonance spectroscopy MRS techniques to better measure brain chemistry and activity. The study focuses on healthy adults aged 18 to 65 and aims to support research into psychiatric illnesses by enhancing brain metabolite imaging methods. This research is conducted by the National Institute of Mental Health and involves using advanced MRI scanners for detailed brain and muscle imaging. Participants will undergo a screening visit including medical exams, blood and urine tests, and neurological assessments. The study uses existing MRI scans if done within the past year or performs a new MRI scan. Then, participants will have a magnetic resonance spectroscopy MRS scan lasting one to two hours to measure brain metabolites using proton and phosphorous MRS on specialized 3T and 7T MRI scanners. During the study, participants will be monitored for the quality of MR spectroscopy images, focusing on signal-to-noise ratio, lineshape, linewidth, and resolution. The research also tracks improvements in scanner hardware, software, and methods. The total involvement includes screening and scanning visits, with no medications involved, aiming to develop reliable imaging techniques useful for studying psychiatric and neurological disorders.

Development of Magnetic Resonance Spectroscopic Imaging Techniques for Imaging Metabolites in Human Brain and Muscle