In vivo magnetic resonance spectroscopy by transverse relaxation encoding with narrowband decoupling.
Li An, Jun Shen
https://pubmed.ncbi.nlm.nih.gov/37500714Actively Recruiting
Phase Not Applicable
Age: 18Years - 65Years
All Genders
Healthy Volunteers
ID01266577
Development of Magnetic Resonance Spectroscopic Imaging Techniques for Imaging Metabolites in Human Brain and Muscle
Led by National Institute of Mental Health (NIMH) · Updated on 2026-06-08
300
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying brain chemistry and activity using advanced magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) techniques. The goal is to improve and develop new imaging methods that allow detailed measurement of brain metabolites and energy metabolism in healthy adults aged 18 to 65. This research aims to support future studies of psychiatric and neurological disorders by providing better imaging tools. Participants will undergo a screening visit including medical and neurological exams, blood and urine tests, and possibly a clinical MRI to check for brain abnormalities. The main scanning visit uses high-strength MRI scanners to perform proton and phosphorous MRS scans of the brain and muscle. These scans measure various brain chemicals and energy molecules, and the total MRS scan time ranges from one to two hours. The study does not involve medications and uses specialized equipment such as a 7 Tesla scanner and a proton imaging head coil. During participation, individuals will complete screening assessments and then have MRI and MRS scans to collect imaging data. Researchers will evaluate the quality of the spectroscopy images based on signal-to-noise ratio, lineshape, and resolution. They will also monitor improvements in scanner hardware, software, and imaging methods. The study is ongoing and involves healthy volunteers over an extended period, with careful safety and quality controls throughout the process.
CONDITIONS
Brief Title
Development of Magnetic Resonance Spectroscopic Imaging Techniques for Imaging Metabolites in Human Brain and Muscle
Who Can Participate
Age: 18Years - 65Years
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- 18-65 years of age
- Able to give written informed consent
- Healthy based on medical history and physical exam
- Enrolled in Protocol 01-M-0254 or Protocol 17-M-0181
You will not qualify if you...
- Any current Axis 1 diagnosis
- Clinically significant laboratory abnormalities
- Positive HIV test
- Metallic foreign bodies affected by MRI or fear of enclosed spaces preventing MRI
- History of neurological illness or injury affecting study data interpretation
- Inability to lie flat on camera bed for about two and a half hours
- Pregnant or breastfeeding
- Current substance use disorder based on DSM-5
- NIMH employees, staff, and their immediate family members excluded per policy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Diagnostic Evaluation
Duration - 1 day
Participants undergo a clinical MRI scan to ensure no abnormal brain conditions are present before spectroscopy imaging.
1 visit (in-person)
Imaging Sessions
Duration - 1 to 2 hours per session
Participants receive proton and/or phosphorous magnetic resonance spectroscopy scans to measure brain and muscle metabolites using specialized MRI scanners.
1 to multiple visits depending on scan parameters
Trial Site Locations
Total: 1 location
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
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Research Team
C
Christopher S Johnson
L
Li An, Ph.D.
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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