Actively Recruiting
Development of a MHBC Intervention for Weight Loss and Smoking Cessation for Pre-Bariatric Surgery Patients
Led by Yale University · Updated on 2026-03-19
20
Participants Needed
1
Research Sites
95 weeks
Total Duration
On this page
Sponsors
Y
Yale University
Lead Sponsor
A
American Society for Metabolic and Bariatric Surgery
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this research study is to develop and pilot a multiple health behavior change intervention for weight loss and smoking cessation using medication (Naltrexone + Bupropion) and behavior therapy in adults seeking bariatric surgery.
CONDITIONS
Official Title
Development of a MHBC Intervention for Weight Loss and Smoking Cessation for Pre-Bariatric Surgery Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Actively considering bariatric surgery
- Smoke at least 5 cigarettes daily for the past 3 months
- Have a body mass index (BMI) of 30.0 kg/m2 or higher
- Not currently taking medications that interact with Naltrexone or Bupropion
- No history of medical conditions contraindicated with Naltrexone or Bupropion
- Physically able to participate in the intervention (e.g., walk independently)
- Able to speak, read, and write in English
- Between 18 and 65 years old
- Not pregnant, breastfeeding, or planning pregnancy during the study
- No active suicidal or homicidal thoughts
You will not qualify if you...
- History or risk of seizures or conditions that lower seizure threshold
- History of anorexia nervosa or bulimia nervosa
- Currently taking medications contraindicated with Naltrexone or Bupropion
- Allergy or sensitivity to Naltrexone or Bupropion
- Co-existing psychiatric conditions requiring hospitalization or intensive treatment
- Untreated high blood pressure or elevated heart rate
- History of heart disease, cardiac arrhythmias, cerebrovascular diseases including stroke
- Uncontrolled Type I or Type 2 diabetes mellitus
- Severe kidney, liver, neurological, lung, or gallbladder disease or other unstable conditions
- Currently breastfeeding, pregnant, or not using reliable birth control
- Active suicidal or homicidal ideation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Yale University
New Haven, Connecticut, United States, 06511
Actively Recruiting
Research Team
C
Caitlin E Smith, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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