Development and Optimization of MRI Protocols with Neuro-physiological Measurements in Healthy and Patient Volunteers

What this Trial Is About

Researchers are working to develop and improve MRI scanning techniques and related neuro-physiological measurements in both healthy volunteers and patients with various conditions. The goal is to enhance the quality and usefulness of images that assess anatomical, functional, or metabolic brain information, using the latest technology in clinical MRI and other brain exploration equipment. This research is conducted by the University Hospital of Grenoble as part of ongoing efforts to keep their brain imaging tools at the forefront of medical technology. Participants will undergo MRI scans using advanced protocols that may include functional MRI, diffusion tensor imaging, and anatomical imaging. During the MRI sessions, additional devices will monitor eye movements, electrodermal resistance, blood pressure, pulse, breathing, near-infrared spectroscopy for oxygenation measurements, and transcranial electrical stimulation. These procedures aim to optimize imaging sequences and stimulation designs considering the experimental setup and physiological measurements. During the study, participants will be monitored closely while undergoing MRI sessions lasting between one and three hours. Researchers will collect data on brain imaging signals and physiological responses, including eye movement and blood pressure, to evaluate the new protocols. Participants will provide informed consent and be observed for any contraindications or safety concerns. The study includes healthy volunteers and patients, with continuous oversight to ensure data quality and participant safety throughout the research period ending in September 2026.

Development of MRI Protocols and Associated Neuro-physiological Explorations in Healthy and Pathological Subjects