Actively Recruiting

Phase Not Applicable
Age: 18Years +
All Genders
Healthy Volunteers
NCT02535702

Development Of Neuroimaging Methods To Assess The Neurobiology Of Addiction

Led by National Institute on Alcohol Abuse and Alcoholism (NIAAA) · Updated on 2026-05-07

192

Participants Needed

1

Research Sites

548 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Background: Abusing alcohol, drugs, and other substances can cause serious health problems. These substances also can affect brain function. Researchers want to learn more about brain function by using magnetic resonance imaging (MRI). This uses a magnetic field and radio waves to take pictures of the brain. Objective: To develop new ways to use MRI to study the brain. Eligibility: Healthy people 18 years of age or older. Design: Participants will be screened with a medical history, physical exam, and blood and urine tests. They will answer questions about their drug use and psychiatric history. They will be asked about family history of alcoholism or drug abuse. Participants will answer questions to see if they can participate in MRI. Participants will have MRI scans. The scanner is a metal cylinder in a strong magnetic field. Participants will lie on a table that slides in and out of the cylinder. A device called a coil may be placed over the head. Each sub-study will include up to 3 different MRI visits. Participants can be in multiple sub-studies. But they can have only 1 MRI per week and 20 per year. During MRI visits, participants may have urine collected. They may get another MRI questionnaire. Participants may have a clinical MRI brain scan. This may show physical problems in the brain. During some scans, participants may perform simple movement, memory, and thinking tasks. Participants may be connected to a machine to monitor brain activity during the scan. Small metal electrodes will be placed on the scalp. A gel will be placed in the space between the electrodes and the scalp. ...

CONDITIONS

Official Title

Development Of Neuroimaging Methods To Assess The Neurobiology Of Addiction

Who Can Participate

Age: 18Years +
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Eighteen years or older.
  • Ability to provide written informed consent as determined by physical examination and verbal communication.
  • Willingness to abstain from drug use on scheduled testing days.
Not Eligible

You will not qualify if you...

  • Positive urine pregnancy test in females.
  • Presence of ferromagnetic objects contraindicated for MRI or fear of enclosed spaces.
  • Claustrophobia.
  • Body weight over 550 lbs.
  • Current psychiatric disorder diagnosis (other than nicotine/caffeine use disorders).
  • Past severe mental disorder requiring hospitalization or chronic medication.
  • Monthly binge drinking for the last 10 years.
  • Serious neurological disorders such as MS, Parkinson's Disease, ALS, sensory loss, or peripheral neuropathy.
  • Current use of psychoactive drugs excluding caffeine and PRN medications.
  • Clinically significant lab or exam results.
  • Investigators, staff, and their immediate family members.
  • Non-English speakers unable to read and comprehend English.

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

National Institutes of Health Clinical Center

Bethesda, Maryland, United States, 20892

Actively Recruiting

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Research Team

D

Dardo G Tomasi, Ph.D.

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NA

Model

SINGLE_GROUP

Primary Purpose

BASIC_SCIENCE

Number of Arms

9

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