Developing a New Rapid Test to Help Eliminate Onchocerciasis and Related Infections in Adults

What this Trial Is About

Researchers are studying onchocerciasis river blindness, a leading cause of infectious blindness worldwide, mainly affecting Africa. The study aims to develop and evaluate a new rapid diagnostic test to improve detection of onchocerciasis, especially in areas where related parasitic infections like loiasis and mansonellosis occur. This is part of the World Health Organizations 2021-2030 roadmap to eliminate onchocerciasis transmission by improving diagnostic tools. The study involves cross-sectional research conducted over one year in Cameroon, targeting adults 18 and older. Participants include people without filariasis and those mono-infected with Onchocerca volvulus, Loa loa, or Mansonella perstans. After screening and consent, blood and feces samples are collected from participants. Blood is processed and stored at very low temperatures before being sent to a laboratory for development and evaluation of the new diagnostic test. Participants will undergo initial screening to diagnose filarial infections, followed by sample collection if eligible. Researchers will update data on disease prevalence and assess the performance of the new test over 52 weeks. The study includes careful sample handling and transport, with results intended to support onchocerciasis control programs. The total involvement includes screening, sample collection, and follow-up during the study period.

Development of a New Rapid Diagnostic Test to Support Onchocerciasis Elimination