Actively Recruiting
Development of a Novel Stress Testing Protocol to Define the Relationship Between Coronary Microvascular Dysfunction and Diastology in Women With Angina But No Evidence of Obstructive Coronary Artery Disease
Led by Cedars-Sinai Medical Center · Updated on 2023-09-01
30
Participants Needed
1
Research Sites
839 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Microvascular coronary dysfunction (MCD) (abnormities in small blood vessels/arteries in heart) with symptoms of persistent chest pain, primarily impacts women. There are an estimated 2-3 million women in the US with MCD and about 100,000 new cases annually. Recent data from our research group suggests that coronary microvascular disease impairs the way the heart relaxes. This pilot study will attempt to exacerbate this phenotype in an effort to better understand the pathophysiology of the disease. The investigators will recruit 30 volunteers total (10 healthy calibration subjects, 10 women with microvascular disease, and 10 age-match women for the group with microvascular disease). Subjects will undergo a series of "stress" maneuvers in conjunction with advanced cardiac magnetic resonance imaging.
CONDITIONS
Official Title
Development of a Novel Stress Testing Protocol to Define the Relationship Between Coronary Microvascular Dysfunction and Diastology in Women With Angina But No Evidence of Obstructive Coronary Artery Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Fully understand and willing to undergo study procedures
- Male or female aged 18 years or older
- Understand and willing to sign consent form
You will not qualify if you...
- History of cardiovascular, pulmonary, or neurological disease
- Hypertension with sitting blood pressure over 140/90 mmHg on at least 2 occasions
- Diabetes
- Unable to give informed consent
- Contraindication to cardiac MRI, including claustrophobia and metallic implants
- Issues with adherence or retention
- Pregnant women
- Allergy to animal dander
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Cedars-Sinai Medical Center
Los Angeles, California, United States, 90048
Actively Recruiting
Research Team
B
Barbra Streisand Women's Heart Center
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
DIAGNOSTIC
Number of Arms
3
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