Actively Recruiting
Development of Patient Derived Xenografts (PDX) in Patients With Breast Cancer
Led by Mayo Clinic · Updated on 2026-03-03
999
Participants Needed
1
Research Sites
1096 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Breast cancer patients who undergo neoadjuvant systemic therapy and have residual breast cancer identified at the time of surgery exhibit a high (\>50%) risk of future life-threatening recurrences and death.
CONDITIONS
Official Title
Development of Patient Derived Xenografts (PDX) in Patients With Breast Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Diagnosis of invasive breast cancer treated with neoadjuvant systemic therapy
- Breast cancer that can be surgically removed after neoadjuvant systemic treatment
- Received at least 2 weeks of neoadjuvant endocrine therapy or at least 2 months of neoadjuvant chemotherapy with signs of remaining cancer on imaging
- Began neoadjuvant chemotherapy or endocrine therapy but stopped due to evidence of cancer progression by MRI, ultrasound, or physical exam
- Provided written informed consent
- Willing to return to the enrolling institution for breast cancer surgery
- Willing to provide blood specimens for research at Mayo Clinic
- Willing to provide tissue specimens for research at Mayo Clinic
- Willing to provide tissue specimens for growing PDX and organoids for future research at Mayo Clinic
You will not qualify if you...
- Not eligible for surgery
- History of another cancer within 3 years before registration, except for non-melanoma skin cancer, papillary thyroid cancer, or non-invasive cancers like carcinoma in situ of the cervix
AI-Screening
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Trial Site Locations
Total: 1 location
1
Mayo Clinic
Rochester, Minnesota, United States, 55905
Actively Recruiting
Research Team
C
Clinical Trials Referral Office
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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