Creating a New Model to Guide Propofol Use in Adults Aged 65 to 99 Using Brain Activity Monitoring

What this Trial Is About

Researchers are studying the administration of Propofol, an intravenous anesthetic, in adults older than 65 years. The goal is to develop a pharmacodynamic model based on a new parameter derived from frontal electroencephalogram EEG data. This model aims to better predict the hypnotic effect of Propofol in older adults, addressing limitations in existing models that use the bispectral index BIS and underrepresent this age group. Participants will receive an intravenous infusion of Propofol with preset plasma concentration targets. During administration, continuous monitoring of BIS values, frontal EEG, and clinical signs of consciousness will be performed. Two modelsthe existing BIS-based model and the new EEG-based modelwill be created and compared to evaluate their predictive ability. Participants will complete preoperative questionnaires and undergo Propofol infusion with simultaneous BIS and EEG monitoring to track clinical signs of loss and return of consciousness. Researchers will measure performance error, prediction errors, and timing of consciousness changes using EEG data. The study aims to improve Propofol dosing in older adults to avoid under- or overdosing effects. The trial duration extends until August 2026.

Development of a Pharmacodynamic Model for Propofol in Older Adults