Actively Recruiting
Development of a Pharmacodynamic Model for Propofol in Older Adults
Led by Pontificia Universidad Catolica de Chile · Updated on 2025-05-31
60
Participants Needed
1
Research Sites
60 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this pharmacodynamic study is to develop a model for Propofol administration for older adults (\>65 years). The main objective is to create a model based on a new pharmacodynamic parameter, derived from frontal electroencephalogram (EEG), to admininster Propofol in older adults. With this new model, the investigators aim to: * Evaluate the relationship between the plasmatic concentration, described by the Eleveld pharmacokinetic model, versus the effect of the drug represented with a new parameter derived from the intraoperative frontal EEG. * To validate the predictive ability of Eleveld's pharmacokinetic-pharmacodynamic model, based on the bispectral index (BIS), compared to the new model based on a parameter derived from intraoperative frontal EEG. Participants will be asked to answer preoperative questionnaires, receive a Propofol intravenous infusion concomitantly with continuous BIS and EEG monitoring, and to be evaluated for clinical sings of loss and return of consciousness.
CONDITIONS
Official Title
Development of a Pharmacodynamic Model for Propofol in Older Adults
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients undergoing non-cardiac elective surgery requiring general anesthesia
- American Society of Anesthesiologists Physical Status I to III
- Adults aged 65 to 99 years
You will not qualify if you...
- Patients undergoing emergency surgery
- Neurosurgical patients
- History of alcohol abuse or recreational drug use
- Known allergy to Propofol
- Body mass index 6 35 Kg/m2
- Unstable heart failure
AI-Screening
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Trial Site Locations
Total: 1 location
1
Pontificia Universidad Católica de Chile
Santiago, Santiago Metropolitan, Chile, 8330024
Actively Recruiting
Research Team
J
Juan C. Pedemonte, MD
CONTACT
L
Luis I. Cortinez, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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