Actively Recruiting
Development of a Platform for the Clinical Implementation of Precision Oncology in the Central-Southern Regions of Italy (COESIT)
Led by National Cancer Institute, Naples · Updated on 2025-03-25
16000
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are working to establish a network of reference laboratories in the central-southern regions of Italy to improve the genetic and molecular understanding of tumors. The goal is to support the use of precision and personalized oncology in clinical practice by studying tumor genetics and identifying important biomarkers that may guide treatment decisions. The project involves upgrading laboratory technology and standardizing procedures for sequencing and bioinformatics across participating institutions. A shared database will be created to combine genetic sequencing data with clinical and pathological information. This will include both retrospective and prospective data collection, such as patients' lifestyle and environmental exposures, genetic profiles of tumors, and germline alterations in individuals at risk for breast and gastric cancers. Participants will provide informed consent for the collection and analysis of their clinicopathological and genomic data. Researchers will analyze correlations between tumor genetics and therapy response, especially in patients who did not respond to targeted treatments. The main outcome measured is the improvement of diagnostic precision in oncology using advanced molecular profiling over a four-year period. This observational, multicenter study allows researchers to deepen knowledge of tumor genetics and support precision medicine in the region.
CONDITIONS
Brief Title
Development of a Platform for the Clinical Implementation of Precision Oncology in the Central-Southern Regions of Italy (COESIT)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Cancer patients
- Patients from the central-southern regions
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Ongoing during clinical care
Participants undergo comprehensive genomic profiling and collection of clinicopathological information as part of routine clinical practice or local genomic screening programs.
Visits as part of routine healthcare
Duration - Up to 4 years
Participants who undergo routine care are observed for correlation between genomic biomarkers and therapy response, and for identification of new prognostic and predictive factors.
Visits aligned with clinical follow-up schedules
Trial Site Locations
Total: 1 location
1
Istituto Nazionale Tumori di Napoli - IRCCS - Fondazione G. Pascale
Naples, Italy, 80131
Actively Recruiting
Research Team
A
Antonella De Luca
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here