Building a Network and Platform for Precision Cancer Care in Central-Southern Italy

What this Trial Is About

Researchers are working to establish a network of reference laboratories in the central-southern regions of Italy to improve the genetic and molecular understanding of tumors. The goal is to support the use of precision and personalized oncology in clinical practice by studying tumor genetics and identifying important biomarkers that may guide treatment decisions. The project involves upgrading laboratory technology and standardizing procedures for sequencing and bioinformatics across participating institutions. A shared database will be created to combine genetic sequencing data with clinical and pathological information. This will include both retrospective and prospective data collection, such as patients lifestyle and environmental exposures, genetic profiles of tumors, and germline alterations in individuals at risk for breast and gastric cancers. Participants will provide informed consent for the collection and analysis of their clinicopathological and genomic data. Researchers will analyze correlations between tumor genetics and therapy response, especially in patients who did not respond to targeted treatments. The main outcome measured is the improvement of diagnostic precision in oncology using advanced molecular profiling over a four-year period. This observational, multicenter study allows researchers to deepen knowledge of tumor genetics and support precision medicine in the region.

Development of a Platform for the Clinical Implementation of Precision Oncology in the Central-Southern Regions of Italy (COESIT)