Actively Recruiting
Development of Quantitative Muscle Imaging as a Biomarker of Disease Endpoints in Myotonic Dystrophy
Led by Wake Forest University Health Sciences · Updated on 2026-01-23
75
Participants Needed
1
Research Sites
206 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Myotonic dystrophy (dystrophia myotonica; DM), the most prevalent form of muscular dystrophy in adults, is characterized by progressive myopathy, myotonia, and multi-systemic involvement. DM causes severe disability and profoundly affects the patient's quality of life. Currently, no effective treatments are available that alter the course of the disease, but ongoing clinical trials are underway.
CONDITIONS
Official Title
Development of Quantitative Muscle Imaging as a Biomarker of Disease Endpoints in Myotonic Dystrophy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Ages 18 to 65 years
- Diagnosis of DM1 or DM2 by clinical or genetic criteria; if diagnosed clinically, a first-degree relative must have genetic testing confirmation and consent to release genetic information
- Clinically affected by muscle weakness or myotonia
- Able to walk independently without a walker
- Able to give informed consent
- For control subjects: healthy with no significant medical or neurological conditions
- Control subjects aged 18 to 65 years
- Control subjects able to give informed consent
You will not qualify if you...
- Presence of cardiac pacemaker, defibrillator, metal implants, or other MRI contraindications
- Use of anabolic or catabolic agents within one year before study entry
- History of lumbar spine or leg surgery, lumbar radiculopathy, or peripheral neuropathy
- Body mass index (BMI) greater than 35
- Pregnancy
- For muscle biopsy: history of bleeding disorders or use of anticoagulation
- Use of nonsteroidal anti-inflammatory agents within 7 days before muscle biopsy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Wake Forest University Health Sciences
Winston-Salem, North Carolina, United States, 27157
Actively Recruiting
Research Team
E
Elizabeth (Gracie) G Hilber
CONTACT
C
Constance Linville
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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