Actively Recruiting
Development of a Therapeutic Endpoint in Pediatric Rheumatologic Conditions
Led by Children's National Research Institute · Updated on 2026-04-06
90
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying a new way to measure pain and treatment effects in children and young adults with three different rheumatology conditions: Juvenile Idiopathic Arthritis (JIA), Systemic Lupus Erythematosus (SLE), and Fibromyalgia (FM). The goal is to create an objective pain measurement that can help improve treatment decisions and avoid trial-and-error approaches. This is a single-site observational study without randomization or blinding. Participants are children and young adults aged 5 to 21 years diagnosed with JIA, SLE, or FM. Since this is an observational study, no new treatments are given as part of the research, and patients continue their usual care. The study will follow participants for one year, collecting data during their routine clinic visits. Participants will have baseline measurements taken at enrollment and at follow-up visits as part of their standard care over one year. Researchers will observe how the nociceptive index, a measure related to pain, behaves in these populations and how it responds to usual treatments. The study will assess safety and treatment effects through ongoing monitoring without altering patient care.
CONDITIONS
Brief Title
Development of a Therapeutic Endpoint in Pediatric Rheumatologic Conditions
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female aged 5 years or older at screening
- Diagnosis of Juvenile Idiopathic Arthritis (JIA), Systemic Lupus Erythematosus (SLE), or Fibromyalgia (FM) confirmed by medical history
You will not qualify if you...
- History of eye disease that prevents pupillometry measurements
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 year
Participants are observed over time to characterize disease progression and treatment effects in pediatric rheumatologic conditions.
Regular visits for assessments as per disease condition
Trial Site Locations
Total: 1 location
1
Children's National Health System
Washington D.C., District of Columbia, United States, 20010
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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