Actively Recruiting
Development of a Transdiagnostic Intervention for Adolescents at Risk for Serious Mental Illness
Led by Massachusetts General Hospital · Updated on 2026-06-05
70
Participants Needed
1
Research Sites
8 weeks
Total Duration
On this page
Sponsors
M
Massachusetts General Hospital
Lead Sponsor
N
National Institute of Mental Health (NIMH)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are developing a brief group-based treatment called Resilience Training for Teens to support high school students aged 14 to 19 who have mild symptoms of depression, anxiety, or unusual feelings. The study aims to test how well this intervention protects these teens from developing serious mental illnesses. This is an interventional study sponsored by Massachusetts General Hospital that uses a randomized design to evaluate the program's effect. Participants will be randomly assigned to one of two groups. One group will receive the Resilience Training for Teens, a brief behavioral intervention delivered over 6 group sessions. The other group will be placed on a one-year waitlist without participating in the training initially but will be offered the program after this period. The study compares outcomes between those who receive the intervention immediately and those who wait. During the study, teens will be monitored for changes using interviews and behavioral assessments at one year. Researchers will use tools like the Structured Interview of Psychosis-risk Syndromes (SIPS), Child Behavior Checklist, and Global Functioning Social and Role Scales to evaluate mental health and social functioning. Parent involvement is also part of the study, including a parent session and consent process. The total participation time includes the intervention period and one-year follow-up to assess the program's impact and safety.
CONDITIONS
Brief Title
Development of a Transdiagnostic Intervention for Adolescents at Risk for Serious Mental Illness
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Currently enrolled in 9th through 12th grade and between the ages of 14 and 19
- Endorsed at least one psychotic experience
- Provided contact information
- Have a parent or legal guardian who is able and willing to provide written informed consent (if under the age of 18)
- Have a parent or legal guardian who is able and willing to participate in a parent session
- Competent and willing to provide written informed assent (if under the age of 18) or consent (if age 18 or older)
- Able to communicate in English
You will not qualify if you...
- Currently prescribed psychotropic medication (not including medications for attention deficit/hyperactivity disorder), regardless of adherence
- Currently obtaining psychotherapeutic intervention
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 6 sessions
Participants undergo a brief 6-session group-based behavioral intervention designed to build resilience and reduce risk of serious mental illness.
Weekly visits for 6 weeks
Duration - 1 year
Participants are monitored for outcomes related to mental health and functioning for up to 1 year after the intervention or waitlist period.
Periodic assessments during the 1-year follow-up
Trial Site Locations
Total: 1 location
1
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114
Actively Recruiting
Research Team
N
Nicole R DeTore, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here