Actively Recruiting
Dexamethasone for Cerebral Toxoplasmosis
Led by Universitas Padjadjaran · Updated on 2024-07-03
138
Participants Needed
1
Research Sites
219 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Toxoplasma gondii infects over one third of the global human population. Cerebral toxoplasmosis is the most common opportunistic infection in HIV patients resulting in up to 50% of mortality with proper treatment and 80% without it. The fatality mainly due to the brain edema resulted from the mass effect lesion. In addition of anti toxoplasmosis given, adjunctive therapy such as steroid is recommended in order to reduce brain edema, but the dose and duration of administration in cerebral toxoplasmosis has not been evaluated in a clinical trial. Adjunctive therapy given in cerebral toxoplasmosis patients still remains unclear. Moreover, its safety in immunodeficiency cases is still debatable.
CONDITIONS
Official Title
Dexamethasone for Cerebral Toxoplasmosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or above
- Clinical signs and symptoms compatible with cerebral toxoplasmosis
- Positive HIV serology
- Positive immunoglobulin G anti-toxoplasma titre
- One or more mass lesions on neuroradiological imaging
- Dexamethasone therapy taken for none or less than 3 days
- Written informed consent from patient or close relatives if patient is unconscious
You will not qualify if you...
- Anti-toxoplasmosis treatment taken for more than 5 days before recruitment
- Hypersensitivity or contraindication to dexamethasone
- Pregnancy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Hasan Sadikin General Hospital
Bandung, West Java, Indonesia, 40161
Actively Recruiting
Research Team
A
Ahmad R Ganiem, M.D., PhD
CONTACT
S
Sofiati Dian, M.D., PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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