What is this study about regarding pain control after cesarean section?

This study is evaluating how adding dexamethasone or magnesium sulfate to bupivacaine affects pain control after cesarean delivery under spinal anesthesia. Researchers want to find better ways to manage postoperative pain to help recovery. The study is sponsored by Cairo University.

Who may be eligible for this cesarean section clinical trial?

Women aged 18 to 35 years who are full-term and scheduled for elective cesarean delivery under spinal anesthesia may be eligible. Participants should be generally healthy without significant chronic diseases or allergies to the study drugs. Please review eligibility criteria for more details.

Is there any cost to participate in this cesarean section clinical trial?

Study-related care, including the study drugs and all trial visits, is provided at no cost. However, personal travel expenses may vary and are not guaranteed to be covered.

Actively Recruiting

Phase Not Applicable

Age: 18Years - 35Years

All Genders

ID07139522

Comparing Dexamethasone and Magnesium Sulphate Added to Bupivacaine for Postoperative Pain Relief After Elective Cesarean Section with Spinal Anesthesia

Led by Cairo University · Updated on 2025-08-24

150

Participants Needed

Research Sites

N/A

Total Duration

AI-Summary

What this Trial Is About

This research aims to compare the effects of adding dexamethasone or magnesium sulfate to bupivacaine during bilateral erector spinae plane blocks for controlling pain after cesarean section under spinal anesthesia. The study focuses on women undergoing elective cesarean delivery and explores ways to improve postoperative pain management, which is important to support recovery and reduce complications like chronic pain and stress. Participants will be divided into three groups one receiving 20 ml of 0.25% isobaric bupivacaine alone, another receiving 20 ml of the same bupivacaine plus 4 mg dexamethasone, and the third receiving 20 ml of bupivacaine with 200 mg magnesium sulfate. These treatments are delivered using ultrasound-guided erector spinae plane blocks during surgery. During the study, participants will be monitored for pain control, time to first need for additional pain relief, total morphine consumption, ability to move independently, and any complications within 24 hours after surgery. Researchers will assess pain levels, quality of recovery, and safety outcomes to evaluate the effects of the added medications. The study period includes immediate postoperative assessments and follow-up within the first day after cesarean delivery.

CONDITIONS

Brief Title

Dexamethasone Versus Magnesium Sulphate as an Adjuvant to Bupivacaine in Ultrasound Guided Erector Spinae Plane Block for Postoperative Analgesia in Elective Caesarean Section Under Spinal Anesthesia

Who Can Participate

Age: 18Years - 35Years

All Genders

Eligibility Criteria

You may qualify if you...

Age from 18 to 35 years
Full-term, singleton, pregnant women
American Society of Anesthesiologists (ASA) physical status II
Scheduled for elective cesarean delivery under spinal anesthesia

You will not qualify if you...

Refusal of the patient
Emergency caesarean sections
Chronic diseases such as asthma or significant cardiovascular disorders
Renal impairment (Creatinine 2mg/dl, urea 25mg/dL)
Liver impairment (ALT < 45 U/L, AST < 45 U/L)
Allergy to any study drug
Body mass index (BMI) 35 kg/m2
Hypertensive disorders of pregnancy
Contraindications to spinal anesthesia such as coagulopathy or local infection
Requirement for conversion to general anesthesia after spinal anesthesia

Research Team

Esraa E Farrag, Master

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