Actively Recruiting
The Efficacy of Dexamethasone Versus Magnesium Sulphate as an Adjuvant to Bupivacaine in Ultrasound Guided Erector Spinae Plane Block for Postoperative Analgesia in Elective Caesarean Section Under Spinal Anesthesia
Led by Cairo University · Updated on 2025-08-24
150
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to compare the effects of adding dexamethasone or magnesium sulfate to bupivacaine during bilateral erector spinae plane blocks for controlling pain after cesarean section under spinal anesthesia. The study focuses on women undergoing elective cesarean delivery and explores ways to improve postoperative pain management, which is important to support recovery and reduce complications like chronic pain and stress. Participants will be divided into three groups: one receiving 20 ml of 0.25% isobaric bupivacaine alone, another receiving 20 ml of the same bupivacaine plus 4 mg dexamethasone, and the third receiving 20 ml of bupivacaine with 200 mg magnesium sulfate. These treatments are delivered using ultrasound-guided erector spinae plane blocks during surgery. During the study, participants will be monitored for pain control, time to first need for additional pain relief, total morphine consumption, ability to move independently, and any complications within 24 hours after surgery. Researchers will assess pain levels, quality of recovery, and safety outcomes to evaluate the effects of the added medications. The study period includes immediate postoperative assessments and follow-up within the first day after cesarean delivery.
CONDITIONS
Brief Title
Dexamethasone Versus Magnesium Sulphate as an Adjuvant to Bupivacaine in Ultrasound Guided Erector Spinae Plane Block for Postoperative Analgesia in Elective Caesarean Section Under Spinal Anesthesia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age from 18 to 35 years
- Full-term, singleton, pregnant women
- American Society of Anesthesiologists (ASA) physical status II
- Scheduled for elective cesarean delivery under spinal anesthesia
You will not qualify if you...
- Refusal of the patient
- Emergency caesarean sections
- Chronic diseases such as asthma or significant cardiovascular disorders
- Renal impairment (Creatinine 2mg/dl, urea 25mg/dL)
- Liver impairment (ALT < 45 U/L, AST < 45 U/L)
- Allergy to any study drug
- Body mass index (BMI) 35 kg/m2
- Hypertensive disorders of pregnancy
- Contraindications to spinal anesthesia such as coagulopathy or local infection
- Requirement for conversion to general anesthesia after spinal anesthesia
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Single treatment during surgery
Participants receive an ultrasound-guided erector spinae plane block with either bupivacaine alone, bupivacaine with dexamethasone, or bupivacaine with magnesium sulphate during their elective cesarean section under spinal anesthesia.
1 treatment visit (in-person)
Duration - 24 hours postoperatively
Participants are monitored for postoperative pain, analgesic requirements, recovery quality, morphine consumption, mobility, and any complications for 24 hours after surgery.
1 follow-up visit (in-person)
Trial Site Locations
Total: 1 location
1
Cairo University
Cairo, Egypt, 12613
Actively Recruiting
Research Team
E
Esraa E Farrag, Master
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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