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Comparing Single Dose and Continuous Infusion of Dexmedetomidine to Reduce Agitation in Adults Having Nasal Surgery
Led by Fayoum University Hospital · Updated on 2025-03-10
50
Participants Needed
1
Research Sites
4 weeks
Total Duration
AI-Summary
What this Trial Is About
Researchers are evaluating the use of dexmedetomidine to reduce emergence agitation in obese adults undergoing nasal surgery. Emergence agitation is a serious condition that can occur when waking from general anesthesia, leading to risks like self-injury, aspiration, and other complications. This study compares a single bolus dose given before extubation with a continuous infusion to find the most effective way to reduce agitation. The trial is a prospective randomized study sponsored by Fayoum University Hospital and focuses on adults aged 18 to 50 years with a body mass index below 30 undergoing elective nasal surgery. Participants receive either a single dose of dexmedetomidine at 0.5 gkg in saline over 10 minutes starting 15 minutes before the end of surgery or a continuous infusion of dexmedetomidine at 0.5 gkghour during the operation without a loading dose. Standard anesthesia monitoring is used, including electrocardiogram, pulse oximetry, and non-invasive blood pressure. Anesthesia is maintained with isoflurane, and muscle relaxation is reversed before extubation. Patients are then transferred to the postanesthesia care unit PACU once awake, calm, and sedated. Various rescue drugs and supportive care are provided as needed. During the study, participants are closely monitored for heart rate, blood pressure, agitation level using the Richmond Agitation Sedation Scale five minutes after surgery, and other outcomes like extubation time, PACU time, analgesic use, and incidence of side effects. Follow-up occurs up to 24 hours after surgery to assess pain, nausea, vomiting, and surgical field quality. The total participation includes the surgery and post-operative care until discharge from PACU. Statistical analysis will compare the two dexmedetomidine dosing methods to determine their effects on emergence agitation and related outcomes.
CONDITIONS
Brief Title
Dexmedetomidine and Agitation After Nasal Surgery
Research Team
Y
Yasser S Mostafa, MD
M
Mohamed A Shawky, MD
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