Actively Recruiting
Impact of Dexmedetomidine Added to Intra-articular Bupivacaine for Postoperative Analgesia After Knee Arthroscopic Surgery
Led by Al-Azhar University · Updated on 2025-04-22
75
Participants Needed
2
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to compare the pain-relieving effects of adding dexmedetomidine to bupivacaine versus bupivacaine alone after knee arthroscopy, specifically in patients undergoing anterior cruciate ligament (ACL) reconstruction. The study is a prospective, double-blind trial involving 75 patients at Al Azhar University Hospital, focusing on improving postoperative pain management. Participants are randomly assigned to one of three groups: a control group receiving 18 ml of normal saline injected into the knee joint, a group receiving 18 ml of 0.25% bupivacaine injected intra-articularly, and a group receiving dexmedetomidine at 1 mcg/kg added to the bupivacaine injection. All injections are administered through the arthroscope by the surgeon after completing the procedure. During the study, pain levels will be assessed using the visual analog scale (VAS) at multiple time points after surgery, including 30 minutes, 1, 2, 4, 6, 12, and 24 hours. Researchers will also monitor the total consumption of meperidine, an additional pain medication used if pain exceeds a certain level. Safety and effectiveness of the pain relief methods will be closely evaluated throughout the postoperative period.
CONDITIONS
Brief Title
Dexmedetomidine and Bupivacaine Intra-articular for Postoperative Analgesia After Knee Arthroscopic Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- ASA I-II patients
- Any gender
- Aged 18 to 65 years
- Candidates for anterior cruciate ligament (ACL) reconstruction by knee arthroscopy
You will not qualify if you...
- Patients with kidney failure, liver failure, valvular or ischemic heart disease, high blood pressure, diabetes, history of infection, or malignancy
- History of coagulation disorders or drug allergies to study medications
- Use of NSAIDs or analgesics within 24 hours before surgery
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Day of surgery
Participants undergo knee arthroscopic surgery with an intra-articular injection of either dexmedetomidine, bupivacaine, or normal saline after the procedure to manage postoperative pain.
1 visit (in-person)
Duration - 24 hours post surgery
Participants are monitored for pain levels and analgesic use during the first 24 hours after surgery.
Multiple assessments at 30 minutes, 1, 2, 4, 6, 12, and 24 hours post surgery
Trial Site Locations
Total: 2 locations
1
Al-Azhar University
Asyut, Egypt, 71523
Actively Recruiting
2
Al-Azhar University
Asyut, Egypt
Not Yet Recruiting
Research Team
M
Mohamed A. Mahmoud, MD
W
Warda D.K. Ali, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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