Actively Recruiting
Effect of Perioperative Dexmedetomidine Infusion on Anesthetic Requirements and Quality of Emergence in Patients Undergoing Thyroid Surgery: A Randomized Controlled Trial
Led by Bach Mai Hospital · Updated on 2026-04-15
100
Participants Needed
1
Research Sites
4 weeks
Total Duration
On this page
Sponsors
B
Bach Mai Hospital
Lead Sponsor
H
Hanoi Medical University
Collaborating Sponsor
AI-Summary
What this Trial Is About
This research investigates the use of dexmedetomidine, a drug with sedative and pain-reducing properties, to improve the quality of recovery after thyroid surgery. The study focuses on whether using dexmedetomidine throughout the surgery reduces the need for anesthesia and opioids and lessens coughing, agitation, and blood pressure changes during breathing tube removal. The trial takes place in patients aged 18 to 65 undergoing elective thyroid surgery under general anesthesia. Participants are randomly assigned to one of two groups: one receiving dexmedetomidine along with standard anesthesia, and the other receiving standard anesthesia alone. The dexmedetomidine group gets a loading dose before anesthesia induction followed by continuous infusion during surgery. Both groups have anesthesia managed with monitored techniques to maintain proper sedation and muscle relaxation until the breathing tube is safely removed. During the study, patients will be closely monitored for coughing during extubation, anesthetic and opioid use, agitation after waking, heart rate, blood pressure, pain levels, nausea, bleeding complications, and overall recovery quality. These assessments occur during surgery and up to 24 hours afterward. The total participation duration includes surgery and immediate postoperative care to evaluate the drug's impact on recovery.
CONDITIONS
Brief Title
Dexmedetomidine for Improving Emergence Quality in Thyroid Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18-65 years
- American Society of Anesthesiologists (ASA) physical status I-III
- Scheduled for elective thyroid surgery under general anesthesia with endotracheal intubation
- Able to understand the study procedures and provide written informed consent
You will not qualify if you...
- Known hypersensitivity or contraindication to dexmedetomidine or study-related medications
- Clinically significant cardiac conduction abnormality or arrhythmia (e.g., second- or third-degree atrioventricular block without a pacemaker), severe bradyarrhythmia, or unstable cardiovascular disease
- Severe hepatic dysfunction or severe renal failure
- Pregnancy or breastfeeding
- Planned postoperative ICU admission or postoperative deterioration requiring ICU admission
- Major intraoperative complications such as major bleeding requiring urgent hemostatic intervention, tracheal or esophageal injury, or recurrent laryngeal nerve injury
- Any condition that would interfere with outcome assessment or increase risk, such as inability to reliably report pain scores or complete quality of recovery questionnaires (QoR-15)
AI-Screening
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Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Duration of surgery and immediate recovery (hours)
Participants undergo thyroid surgery under general anesthesia. They receive dexmedetomidine infusion perioperatively as an anesthetic adjunct or standard general anesthesia without dexmedetomidine during surgery.
1 perioperative visit (in-person)
Duration - 24 hours post-surgery
Participants are monitored for postoperative recovery quality, pain, nausea, vomiting, bleeding complications, and other outcomes within 24 hours after surgery.
Multiple assessments within 24 hours after surgery (in-person)
Trial Site Locations
Total: 1 location
1
Center for Anesthesia and Surgical Intensive Care, Bach Mai Hospital
Hanoi, Vietnam
Actively Recruiting
Research Team
T
Thang Toan Nguyen, MD, PhD, Assoc Prof
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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