Actively Recruiting
Dexmedetomidine for Improving Emergence Quality in Thyroid Surgery
Led by Bach Mai Hospital · Updated on 2026-04-15
100
Participants Needed
1
Research Sites
33 weeks
Total Duration
On this page
Sponsors
B
Bach Mai Hospital
Lead Sponsor
H
Hanoi Medical University
Collaborating Sponsor
AI-Summary
What this Trial Is About
Thyroid surgery requires smooth emergence from anesthesia to minimize coughing, hemodynamic fluctuations, and agitation during extubation, which may contribute to postoperative complications such as bleeding or cervical hematoma. Dexmedetomidine, a selective α2-adrenergic receptor agonist, has sedative, analgesic-sparing, and sympatholytic properties that may improve anesthetic stability and recovery quality. This randomized controlled trial aims to evaluate the effectiveness of a continuous perioperative dexmedetomidine regimen initiated at induction of anesthesia and maintained during thyroid surgery. The study will compare dexmedetomidine combined with standard balanced anesthesia versus standard anesthesia alone in terms of anesthetic requirements and emergence quality. The primary hypothesis is that perioperative dexmedetomidine administration reduces anesthetic and opioid requirements and improves emergence quality by decreasing coughing during extubation and hemodynamic responses.
CONDITIONS
Official Title
Dexmedetomidine for Improving Emergence Quality in Thyroid Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18-65 years
- American Society of Anesthesiologists (ASA) physical status I-III
- Scheduled for elective thyroid surgery under general anesthesia with endotracheal intubation
- Able to understand study procedures and provide written informed consent
You will not qualify if you...
- Known hypersensitivity or contraindication to dexmedetomidine or related medications
- Clinically significant cardiac conduction abnormalities or arrhythmias without pacemaker
- Severe bradyarrhythmia or unstable cardiovascular disease
- Severe liver dysfunction or severe kidney failure
- Pregnancy or breastfeeding
- Planned postoperative ICU admission or deterioration requiring ICU
- Major intraoperative complications such as major bleeding, tracheal or esophageal injury, or nerve injury
- Any condition interfering with outcome assessment or increasing risk as judged by investigator
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Center for Anesthesia and Surgical Intensive Care, Bach Mai Hospital
Hanoi, Vietnam
Actively Recruiting
Research Team
T
Thang Toan Nguyen, MD, PhD, Assoc Prof
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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