Actively Recruiting
Impact of Dexmedetomidine and Ketamine and Their Combination for the Reduction of Postoperative Morphine Requirements After VATS Surgery
Led by Ciusss de L'Est de l'Île de Montréal · Updated on 2024-12-02
120
Participants Needed
1
Research Sites
30 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying postoperative pain management in patients undergoing elective video-assisted thoracic surgery (VATS) for lung resection. This study focuses on comparing the effects of two non-opioid drugs, ketamine and dexmedetomidine, alone and in combination, to reduce the need for morphine after surgery. The goal is to see if combining these drugs can further decrease morphine use by 30% within 24 hours after surgery, which may improve recovery and reduce opioid-related side effects. The study involves three groups of patients receiving different intraoperative infusions: ketamine alone, dexmedetomidine alone, or a combination of ketamine and dexmedetomidine. Each drug is given as a bolus followed by continuous infusion during surgery. All participants receive opioid patient-controlled analgesia (PCA) along with acetaminophen and NSAIDs for postoperative pain control. The study lasts about one year and uses a randomized, double-blind design to compare morphine consumption and other pain-related outcomes. Participants will be closely monitored during and after surgery, with assessments of morphine use, pain scores at rest and during coughing at 24 and 48 hours, intraoperative fentanyl use, time to chest tube removal, hospital discharge timing, and the presence of chronic pain after three months. Side effects like ketamine-induced psychomimetic reactions and episodes of slow heart rate during surgery will also be recorded. These measures aim to understand better how these drug infusions affect pain management and recovery after VATS.
CONDITIONS
Brief Title
Dexmedetomidine and Ketamine in VATS Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged 18-80 years old
- American Society of Anesthesiology physical status I-III
- Elective Video-Assisted Thoracic Surgery for pulmonary resection
You will not qualify if you...
- Planned use of regional anesthesia technique for postoperative analgesia
- Preoperative use of beta-blockers
- Chronic pain patients taking more than 60 mg morphine orally daily or equivalent
- Use of pregabalin, gabapentin, amitriptyline, nortriptyline, or duloxetine
- Documented allergy to ketamine and/or dexmedetomidine
- Pregnancy
- Inability to give informed consent
- Linguistic barrier
- Patient refusal
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Day of surgery
Participants undergo elective video-assisted thoracic surgery (VATS) and receive an intraoperative infusion of ketamine, dexmedetomidine, or their combination to reduce postoperative morphine requirements.
1 surgical visit (in-person)
Duration - Up to 3 months
Participants are monitored for postoperative pain, morphine consumption, chest tube removal, and side effects up to 3 months after surgery.
Multiple visits including assessments at 24 hours, 48 hours, 1 week, and 3 months post-surgery
Trial Site Locations
Total: 1 location
1
Ciusss
Montreal, Quebec, Canada, H1T2M4
Actively Recruiting
Research Team
V
Veronique Brulotte, MD
N
Nadia Godin, RN
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
3
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