Actively Recruiting
Dexmedetomidine and Ketamine in VATS Surgery
Led by Ciusss de L'Est de l'Île de Montréal · Updated on 2024-12-02
120
Participants Needed
1
Research Sites
438 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Postoperative pain after VATS surgery is significant and associated with moderate to high post operative morphine requirements, which can cause opioid related side effects and delay postoperative recovery. To reduce this requirement, multimodal analgesia with non opioid medication such as dexmedetomidine and ketamine can be used. These drugs have demonstrated significant opioid-sparing properties after various types of surgeries. However, very little is known about their ability to do so in VATS surgery. Also, their relative opioid-sparing properties have not been compared, and it is not known whether their combined use can lead to an additional opioid-sparing effect. The primary goal of this study will be to determine the impact of a combined intra operative infusion of ketamine and dexmedetomidine on postoperative morphine requirements in patients undergoing elective VATS, compared to both these drugs infused separately. The hypothesis is that this combined infusion will lead to a 30% further reduction in morphine requirements, 24h after surgery, compared to both these drugs infused separately.
CONDITIONS
Official Title
Dexmedetomidine and Ketamine in VATS Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged 18-80 years old
- American Society of Anesthesiology physical status I-III
- Elective Video-Assisted Thoracic Surgery for pulmonary resection
You will not qualify if you...
- Planned use of regional anesthesia technique for postoperative analgesia
- Taking beta-blockers before surgery
- Chronic pain requiring more than 60 mg daily oral morphine or equivalent
- Currently taking pregabalin, gabapentin, amitryptillin, nortryptillin, or duloxetin
- Known allergy to ketamine or dexmedetomidine
- Pregnancy
- Unable to give informed consent
- Language barrier preventing understanding of study
- Patient refusal to participate
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Ciusss
Montreal, Quebec, Canada, H1T2M4
Actively Recruiting
Research Team
V
Veronique Brulotte, MD
CONTACT
N
Nadia Godin, RN
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
3
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