Study Comparing Dexmedetomidine, Magnesium Sulfate, and Lidocaine for Reducing Cough After General Anesthesia in Adults Aged 21 to 60

What this Trial Is About

This research aims to compare the effectiveness of dexmedetomidine, magnesium sulfate, and lidocaine in reducing cough during the wake-up phase after general anesthesia. The study is a prospective, randomized, controlled, double-blinded trial focused on measuring both the number and severity of coughs during this critical period. Participants will be randomly assigned to receive one of four treatments 10 minutes before the end of surgery dexmedetomidine at 0.5 bcgkg in saline, magnesium sulfate at 30 mgkg IV in saline, lidocaine at 1.5 mgkg in saline, or a saline placebo. Each treatment is given in a 10 ml saline solution. This phase 3 study carefully compares these options to assess their impact on cough suppression during anesthetic emergence. During the study, researchers will monitor cough frequency and severity at 0, 10, 20, 30, and 40 minutes after removal of the breathing tube. Additional measurements include intraoperative heart rate, blood pressure, oxygen levels every 15 minutes, and sedation scores after extubation at set intervals. The study involves adults aged 21 to 60 undergoing surgery under general anesthesia, with careful monitoring to evaluate safety and treatment effects until the end of the observation period.

Dexmedetomidine, Magnesium Sulphate and Lidocaine for Cough Suppression After General Anesthesia