Prophylactic Effect of Dexmedetomidine-midazolam Versus Ketamine-midazolam on Emergence Delirium After Sevoflurane Anesthesia in Pediatric Cardiac Catheterization: A Randomized Controlled Study.

What this Trial Is About

Researchers are evaluating the effects of two drug combinations on emergence delirium in children aged 2 to 6 years undergoing heart catheterization. The study compares Dexmedetomidine plus Midazolam to Ketamine plus Midazolam during sevoflurane anesthesia. This trial is a randomized, controlled study conducted at Kasr El Aini Hospital to understand which combination might influence emergence delirium after anesthesia. Children will be randomly assigned to one of two groups. Group DM will receive Dexmedetomidine (1 g/kg IV over 10 minutes) and Midazolam (0.1 mg/kg IV) at induction, followed by a continuous infusion of Dexmedetomidine (0.5 g/kg/h) and Midazolam (0.1 mg/kg/h). Group KM will receive Ketamine (1 mg/kg IV) and Midazolam (0.1 mg/kg IV) at induction, followed by continuous infusion of Ketamine (1 mg/kg/h) and Midazolam (0.1 mg/kg/h). Participants will be closely monitored during and after the procedure for signs of emergence delirium, which will be assessed 30 minutes after anesthesia. The trial uses quadruple masking to ensure unbiased results. The study will continue until March 2027, and children will receive scheduled care throughout the process under medical supervision.

Dexmedetomidine-Midazolam vs. Ketamine-Midazolam on Emergence Delirium