Actively Recruiting
Comparing Dexmedetomidine-Midazolam and Ketamine-Midazolam to Prevent Emergence Delirium in Children Aged 2 to 6 Undergoing Heart Catheterization
Led by Kasr El Aini Hospital · Updated on 2026-02-27
50
Participants Needed
1
Research Sites
12 weeks
Total Duration
AI-Summary
What this Trial Is About
Researchers are evaluating the effects of two drug combinations on emergence delirium in children aged 2 to 6 years undergoing heart catheterization. The study compares Dexmedetomidine plus Midazolam to Ketamine plus Midazolam during sevoflurane anesthesia. This trial is a randomized, controlled study conducted at Kasr El Aini Hospital to understand which combination might influence emergence delirium after anesthesia. Children will be randomly assigned to one of two groups. Group DM will receive Dexmedetomidine 1 gkg IV over 10 minutes and Midazolam 0.1 mgkg IV at induction, followed by a continuous infusion of Dexmedetomidine 0.5 gkgh and Midazolam 0.1 mgkgh. Group KM will receive Ketamine 1 mgkg IV and Midazolam 0.1 mgkg IV at induction, followed by continuous infusion of Ketamine 1 mgkgh and Midazolam 0.1 mgkgh. Participants will be closely monitored during and after the procedure for signs of emergence delirium, which will be assessed 30 minutes after anesthesia. The trial uses quadruple masking to ensure unbiased results. The study will continue until March 2027, and children will receive scheduled care throughout the process under medical supervision.
CONDITIONS
Brief Title
Dexmedetomidine-Midazolam vs. Ketamine-Midazolam on Emergence Delirium
Research Team
A
Ahmed Elhaddad, Ass.prof.
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