Comparing Dexmedetomidine, Ozone, and Dexamethasone Injections for Long-Term Pain Relief in Carpal Tunnel Syndrome

What this Trial Is About

Researchers are comparing the pain relief effects of three types of local injectionsDexmedetomidine, Ozone, and Dexamethasonein people with carpal tunnel syndrome CTS. CTS is caused by pressure on the median nerve at the wrist, leading to symptoms like numbness and pain. While corticosteroid injections are commonly used to reduce inflammation in mild to moderate CTS, there is no clear guideline on which steroid is best. This study aims to evaluate which injection offers better long-term pain relief and functional improvement in CTS patients. Participants receive one of three treatments an injection of Dexmedetomidine 1 microgramkg combined with lidocaine near the median nerve a single local injection of ozone gas mixed with lidocaine or a single injection of dexamethasone with lidocaine. These injections are administered using similar techniques targeting the wrist area. The study follows a randomized, double-blind design to fairly compare these three treatment options. During the trial, patients will be assessed before treatment and then at 1 week, 4 weeks, 12 weeks, and 24 weeks after injection. Assessments include measuring pain levels and functional status, as well as nerve conduction studies to evaluate median nerve function. Researchers will also track pain medication use during the first 48 hours after injection. The study is sponsored by Tanta University and includes adults aged 20 to 60 with mild to moderate CTS confirmed by ultrasound and nerve studies.

Dexmedetomidine, Ozone and Dexamethasone Local Injection in Carpal Tunnel Syndrome for Pain Relief