Study of Dexmedetomidines Effect on Sevoflurane Dosage to Reduce Stress Response in Laparoscopic Gallbladder Surgery

What this Trial Is About

This research aims to understand how dexmedetomidine affects the minimum alveolar concentration blunting the adrenergic response MAC-BAR of sevoflurane during laparoscopic cholecystectomy. It focuses on whether dexmedetomidine can lower the sevoflurane dose needed to block the bodys stress response to carbon dioxide gas used in surgery and how it influences heart rate and blood pressure. The study compares different doses of dexmedetomidine to see its impact on these responses during surgery. Participants are randomly assigned to one of three groups a control group receiving saline infusions, a low-dose dexmedetomidine group receiving a 75 gh loading dose over 15 minutes followed by a 60 gh maintenance infusion, or a high-dose dexmedetomidine group receiving a 150 gh loading dose followed by a 120 gh maintenance infusion. Infusions start 15 minutes before anesthesia induction, with surgery beginning after at least 30 minutes to ensure steady drug levels. During the study, participants are monitored for the sevoflurane concentration needed to suppress the stress response within 30 minutes after intubation. Researchers also track blood pressure and heart rate at specific times around the pneumoperitoneum inflation of the abdomen with carbon dioxide and observe any adverse events up to 24 hours after surgery. The overall involvement includes detailed monitoring to assess the impact of dexmedetomidine on anesthesia requirements and hemodynamic stability.

Dexmedetomidine Reduces Sevoflurane MAC-BAR During Pneumoperitoneum