Actively Recruiting
Effect of Dexmedetomidine on Sevoflurane Minimum Alveolar Concentration for Attenuating Adrenergic Response to CO2 Pneumoperitoneum: A Randomized Controlled Trial
Led by Fujian Provincial Hospital · Updated on 2024-10-01
90
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to understand how dexmedetomidine affects the minimum alveolar concentration blunting the adrenergic response (MAC-BAR) of sevoflurane during laparoscopic cholecystectomy. It focuses on whether dexmedetomidine can lower the sevoflurane dose needed to block the body's stress response to carbon dioxide gas used in surgery and how it influences heart rate and blood pressure. The study compares different doses of dexmedetomidine to see its impact on these responses during surgery. Participants are randomly assigned to one of three groups: a control group receiving saline infusions, a low-dose dexmedetomidine group receiving a 75 μg/h loading dose over 15 minutes followed by a 60 μg/h maintenance infusion, or a high-dose dexmedetomidine group receiving a 150 μg/h loading dose followed by a 120 μg/h maintenance infusion. Infusions start 15 minutes before anesthesia induction, with surgery beginning after at least 30 minutes to ensure steady drug levels. During the study, participants are monitored for the sevoflurane concentration needed to suppress the stress response within 30 minutes after intubation. Researchers also track blood pressure and heart rate at specific times around the pneumoperitoneum (inflation of the abdomen with carbon dioxide) and observe any adverse events up to 24 hours after surgery. The overall involvement includes detailed monitoring to assess the impact of dexmedetomidine on anesthesia requirements and hemodynamic stability.
CONDITIONS
Brief Title
Dexmedetomidine Reduces Sevoflurane MAC-BAR During Pneumoperitoneum
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 18-45 years
- American Society of Anesthesiologists (ASA) grade I - II
- Patients undergoing elective laparoscopic cholecystectomy
You will not qualify if you...
- Inability to provide informed consent
- History of chronic pain or substance abuse
- Pregnancy
- Body mass index (BMI) ≥ 30 kg/m2
- Known allergies to the study medications
- Intake of medications within the last 72 hours that may interfere with MAC-BAR determination
- Any other condition deemed exclusionary by the investigators
AI-Screening
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Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Approximately 1 day (surgery day and immediate postoperative period)
Participants receive dexmedetomidine or saline infusions during laparoscopic surgery to evaluate effects on anesthetic requirements and stress response.
1 surgery visit and immediate postoperative monitoring
Duration - Up to 24 hours postoperatively
Participants are monitored for adverse events and recovery after surgery.
Approximately 1 postoperative visit
Trial Site Locations
Total: 1 location
1
Fujian Provincial Hospital
Fuzhou, Fujian, China, 350001
Actively Recruiting
Research Team
Y
Yusheng Yao, MD&PhD
S
Sisi Chen, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
3
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