Actively Recruiting
Dexmedetomidine in Reducing Postoperative Delirium in Cardiac Surgery Patients
Led by Xijing Hospital · Updated on 2025-07-22
686
Participants Needed
1
Research Sites
108 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Delirium is a common consequence of cardiac surgery and associates with poor outcomes. Multiple causes can trigger delirium occurence, and it has been hypothesised that sleep disturbances can be one of them. Dexmedetomidine may be effective in reducing delirium. The aim of this study was to demonstrate preoperative dexmedetomidine nasal spray in cardiac surgery patients can reduce postoperative delirium by improving preoperative sleep.
CONDITIONS
Official Title
Dexmedetomidine in Reducing Postoperative Delirium in Cardiac Surgery Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 18 years or older
- Undergoing cardiac surgery with cardiopulmonary bypass
- Able to provide consent
You will not qualify if you...
- History of schizophrenia, epilepsy, Parkinson's disease, myasthenia gravis, neurosurgery, or low Mini-mental State Examination scores
- Sick sinus syndrome, severe bradycardia (heart rate under 50 beats/min), grade II or higher atrioventricular block without pacemaker
- Unable to communicate due to coma, severe dementia, or language barriers before surgery
- Severe liver dysfunction (Child Pugh C), renal dysfunction requiring dialysis, ASA grade V, or expected survival 24 hours or less
- Heart transplant surgery
- Surgery for congenital heart disease
- Deep hypothermic circulatory arrest surgery
- Currently enrolled in another study
- Refusal to participate
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Xijing Hospital
Xi'an, Shaanxi, China, 710032
Actively Recruiting
Research Team
C
Chong Lei, M.D., phd
CONTACT
Z
Zefei Zhang, M.D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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