Comparing Dexmedetomidine and Lidocaine Infusions with General Anesthesia to Manage Chronic Pain After Mastectomy

What this Trial Is About

Researchers are evaluating dexmedetomidine and lidocaine infusions as additional treatments with general anesthesia to manage chronic pain after mastectomy surgery. Chronic pain following breast cancer surgery is a significant issue, especially as more patients undergo these surgeries due to increased survival rates. The study aims to compare the effects of these two drug infusions on pain control after surgery. Participants will be randomly assigned to one of three groups. One group will receive an intravenous dose of dexmedetomidine followed by a continuous infusion during surgery. Another group will receive an intravenous bolus of lidocaine followed by a continuous infusion. The third group will receive a placebo infusion of isotonic saline in the same manner. These treatments are given during the mastectomy procedure. Participants will be monitored during and after surgery for pain levels, heart rate, blood pressure, and morphine use. The main outcome is the occurrence of chronic pain six months after surgery. Additional assessments include time to first pain relief, pain severity at 12 weeks, activity level, quality of life, and the incidence of post-mastectomy pain syndrome. Monitoring continues during the operation and up to six months postoperatively to evaluate the treatments effects and safety.

Dexmedetomidine Versus Lidocaine Infusions as Adjuvants to General Anesthesia for Chronic Pain Management After Mastectomy