Actively Recruiting
Dexmedetomidine Versus Propofol Sedation for Drug-Induced Sleep Endoscopy in Pediatric Obstructive Sleep Apnea
Led by Erin Kirkham · Updated on 2026-05-14
90
Participants Needed
1
Research Sites
221 weeks
Total Duration
On this page
Sponsors
E
Erin Kirkham
Lead Sponsor
N
National Heart, Lung, and Blood Institute (NHLBI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This research study is designed to learn, first, whether two anesthetics have different effects on collapse seen within the upper airway during sleep endoscopy. A second purpose is to learn whether collapse at several levels of the upper airway is associated with obstructive sleep apnea that persists after adenotonsillectomy, the surgery that removes the tonsils and adenoids.
CONDITIONS
Official Title
Dexmedetomidine Versus Propofol Sedation for Drug-Induced Sleep Endoscopy in Pediatric Obstructive Sleep Apnea
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with obstructive sleep apnea by criteria on a sleep study within the last 12 months
- Considered a surgical candidate for adenotonsillectomy by a certified ear, nose, and throat doctor
- Clinical decision that sleep endoscopy before surgery would benefit child due to risk factors like obesity, severe OSA, exam and symptom mismatch, African American race, or age 7 years or older
- Male or female child aged 3.00 to 11.99 years at consent
- Parent or guardian willing and able to sign informed consent
- Parent or guardian able to read, speak, and understand English or Spanish and complete questionnaires
You will not qualify if you...
- Previous adenotonsillectomy or other upper airway surgery except isolated adenoidectomy more than 18 months ago
- Major medical conditions that increase risk or affect study results
- History of allergic reaction or contraindication to propofol, dexmedetomidine, ketamine, or sevoflurane
- Allergy to eggs, egg products, soybeans, or soybean products
- Contraindication to receiving general anesthesia
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Michigan
Ann Arbor, Michigan, United States, 48109
Actively Recruiting
Research Team
B
Brittany Nordhaus
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
DIAGNOSTIC
Number of Arms
2
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